Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACSF3 (Q4G176) - Overview - Molecular Target Synopsis

Protein


ACSF3, Acyl-CoA synthetase family member 3, mitochondrial
Enzyme Classification 6.2.1.-
UniProt Q4G176

Also Known as ACSF3_HUMAN, ACSF3

Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACSF3 is active in the following subcellular-locations: mitochondrion.
GO terms: ACSF3 is active in the following subcellular-locations: mitochondrial matrix, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACSF3 has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCC_2998, K_562, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Jurkat, Clone E6-1, HT, COLO 205

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to ACSF3 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

ACSF3 is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3NYQ_A, 3NYR_A).

(see details)
Molecular Target 3D Synopsis