Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PLK5 (Q496M5) - Overview - Molecular Target Synopsis

Protein


PLK5, Inactive serine/threonine-protein kinase PLK5
UniProt Q496M5

Also Known as PLK5_HUMAN, PLK5, PLK5P

Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
336ENSG00000185988ENST00000454744, ENST00000334770ENSP00000468376, ENSP00000466248Q496M5-1
299ENSG00000185988ENST00000588430ENSP00000465896
299Q496M5-2

Sub-cellular localization


UniProt: PLK5 is active in the following subcellular-locations: cytoplasm, nucleolus, nucleus.
GO terms: PLK5 is active in the following subcellular-locations: cytoplasm, nucleolus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PLK5 has gain in 0 cell-lines, loss in 4 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1975, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to PLK5 there are:
6 structures (6 chains) solved
6 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PLK5 has been screened with compounds ( bioactivities). (see details)