Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SV2C (Q496J9) - Overview - Molecular Target Synopsis

Protein


SV2C, Synaptic vesicle glycoprotein 2C
UniProt Q496J9

Also Known as SV2C_HUMAN, SV2C, KIAA1054

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles., (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin probably binds via extracellular loop 4 (PubMed:27313224). Recognition by BoNT/A relies on both protein-protein and protein-N-glycosylation; glycosylation of Asn-559 increases its affinity for BoNT/A (PubMed:27313224). Also serves as a receptor for the closely related C.botulinum neurotoxin type A2; glycosylation is not essential but enhances the interaction (PubMed:29649119)., (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); note that type D does not usually infect humans. Interacts with SYT1 in a calcium-dependent manner.

6ES1
CRYSTAL STRUCTURE OF THE BINDING DOMAIN FROM BOTULINUM NEUROTOXIN A2 BOUND TO EXTRACELLULAR DOMAIN OF HUMAN RECEPTOR SV2C
RCSB/PDB
Inspect Structure
See all 3D Structures for SV2C

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
727ENSG00000122012ENST00000502798ENSP00000423541Q496J9-1
676ENSG00000122012ENST00000322285ENSP00000316983

Sub-cellular localization


UniProt: SV2C is active in the following subcellular-locations: cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane.
GO terms: SV2C is active in the following subcellular-locations: cell junction, integral component of membrane, integral component of synaptic vesicle membrane, neuron projection, plasma membrane, synaptic vesicle, synaptic vesicle membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SV2C has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: TK_10, RPMI_8226, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-FI, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For SV2C there are:
4 structures (6 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SV2C has been screened with compounds ( bioactivities). (see details)