Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
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Germline Genetics

ftr (Q49610) - Overview - Molecular Target Synopsis

Protein


ftr, Formylmethanofuran--tetrahydromethanopterin formyltransferase
Enzyme Classification 2.3.1.101
UniProt Q49610

Also Known as FTR_METKA, ftr

Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR). Homotetramer composed of two dimers. Dimerization is sufficient for enzyme activity, but tetramerization is required for high thermostability.

2FHJ
CRYSTAL STRUCTURE OF FORMYLMETHANOFURAN: TETRAHYDROMETHANOPTERIN FORMYLTRANSFERASE IN COMPLEX WITH ITS COENZYMES
RCSB/PDB
Inspect Structure
See all 3D Structures for ftr

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
296Q49610-1

Sub-cellular localization


UniProt: ftr is active in the following subcellular-locations: cytoplasm.
GO terms: ftr is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ftr has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ftr there are:
3 structures (12 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis