Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CHRFAM7A (Q494W8) - Overview - Molecular Target Synopsis

Protein


CHRFAM7A, CHRNA7-FAM7A fusion protein
UniProt Q494W8

Also Known as CRFM7_HUMAN, CHRFAM7A

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
412ENSG00000166664ENST00000299847ENSP00000299847Q494W8-1
110ENSG00000166664ENST00000562729ENSP00000455401

Sub-cellular localization


UniProt: CHRFAM7A is active in the following subcellular-locations: membrane.
GO terms: CHRFAM7A is active in the following subcellular-locations: acetylcholine-gated channel complex, integral component of plasma membrane, neuron projection, synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CHRFAM7A has gain in 0 cell-lines, loss in 16 cell-lines and no signal in 989 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 90% identity similarity to CHRFAM7A there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CHRFAM7A has been screened with compounds ( bioactivities). (see details)