Molecular Target Synopsis
Overview
Domains and Structures
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Chemistry
Ligand Efficiency Plot
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csdA (Q46925) - Overview - Molecular Target Synopsis

Protein


csdA, Cysteine desulfurase CsdA
Enzyme Classification 2.8.1.7
UniProt Q46925

Also Known as CSDA_ECOLI, csdA, ygdJ

Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine, and transiently retains the released sulfur atom on a cysteine residue, in the form of a persulfide. Can also desulfinate L-cysteine sulfinate, which is the best substrate of the enzyme. Functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate. Seems to participate in Fe/S biogenesis by recruiting the SufBCD-SufE proteins. Transfers sulfur to CsdE that increases the cysteine desulfurase activity of CsdA. Can also transfer sulfur directly to TcdA/CsdL in vitro. Appears to support the function of TcdA in the generation of cyclic threonylcarbamoyladenosine at position 37 (ct(6)A37) in tRNAs that read codons beginning with adenine. Homodimer. Forms a heterodimer with CsdE.

5FT4
CRYSTAL STRUCTURE OF THE CYSTEINE DESULFURASE CSDA FROM ESCHERICHIA COLI AT 1.996 ANGSTROEM RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for csdA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
401Q46925-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project csdA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For csdA there are:
6 structures (19 chains) solved
6 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis