Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Gene Expression
Gene Copy Number Variation
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gpr (Q46851) - Overview - Molecular Target Synopsis

Protein


gpr, L-glyceraldehyde 3-phosphate reductase
Enzyme Classification 1.1.1.-
UniProt Q46851

Also Known as GPR_ECOLI, gpr, mgrA, yghZ

Catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). The physiological role of gpr is the detoxification of L-GAP, which may be formed by non-enzymatic racemization of GAP. Also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Homotetramer.

4AUB
THE COMPLEX STRUCTURE OF THE BACTERIAL ALDO-KETO REDUCTASE AKR14A1 WITH NADP AND CITRATE
RCSB/PDB
Inspect Structure
See all 3D Structures for gpr

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
346Q46851-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project gpr has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For gpr there are:
3 structures (24 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis