Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RBCMT (Q43088) - Overview - Molecular Target Synopsis

Protein


RBCMT, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic
Enzyme Classification 2.1.1.127
UniProt Q43088

Also Known as RBCMT_PEA, RBCMT

Methylates 'Lys-14' of the large subunit of RuBisCO. Can also use with lower efficiency chloroplastic fructose-bisphosphate aldolases and gamma-tocopherol methyltransferase as substrates, but not a cytosolic aldolase. Homotrimer.

2H21
STRUCTURE OF RUBISCO LSMT BOUND TO ADOMET
RCSB/PDB
Inspect Structure
See all 3D Structures for RBCMT

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
489Q43088-1

Sub-cellular localization


UniProt: RBCMT is active in the following subcellular-locations: chloroplast, plastid.
GO terms: RBCMT is active in the following subcellular-locations: chloroplast.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RBCMT has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RBCMT there are:
7 structures (21 chains) solved
7 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis