Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CYP74A2 (Q40778) - Overview - Molecular Target Synopsis

Protein


CYP74A2, Allene oxide synthase
Enzyme Classification 4.2.1.92
UniProt Q40778

Also Known as C74A2_PARAR, CYP74A2, RPP30

Involved in the biosynthesis of jasmonic acid, a growth regulator that is implicated also as a signaling molecule in plant defense. Acts on a number of unsaturated fatty-acid hydroperoxides, forming the corresponding allene oxides (By similarity).

3DAM
CRYSTAL STRUCTURE OF ALLENE OXIDE SYNTHASE
RCSB/PDB
Inspect Structure
See all 3D Structures for CYP74A2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
473Q40778-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project CYP74A2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For CYP74A2 there are:
3 structures (3 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CYP74A2 has been screened with compounds ( bioactivities). (see details)