Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ZACN (Q401N2) - Overview - Molecular Target Synopsis

Protein


ZACN, Zinc-activated ligand-gated ion channel
UniProt Q401N2

Also Known as ZACN_HUMAN, ZACN, L2, LGICZ, LGICZ1, ZAC

Zinc-activated ligand-gated ion channel.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ZACN is active in the following subcellular-locations: cell membrane.
GO terms: ZACN is active in the following subcellular-locations: integral component of plasma membrane, neuron projection, plasma membrane, synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ZACN has gain in 6 cell-lines, loss in 0 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H345, NCI-H187, NCI-H1092

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


ZACN has been screened with compounds ( bioactivities). (see details)