Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CCT2 (Q3ZBH0) - Overview - Molecular Target Synopsis

Protein


CCT2, T-complex protein 1 subunit beta
UniProt Q3ZBH0

Also Known as TCPB_BOVIN, CCT2

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Interacts with FLCN.

4B2T
THE CRYSTAL STRUCTURES OF THE EUKARYOTIC CHAPERONIN CCT REVEAL ITS FUNCTIONAL PARTITIONING
RCSB/PDB
Inspect Structure
See all 3D Structures for CCT2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
535Q3ZBH0-1

Sub-cellular localization


UniProt: CCT2 is active in the following subcellular-locations: cytoplasm.
GO terms: CCT2 is active in the following subcellular-locations: cell body, chaperonin-containing T-complex, microtubule, zona pellucida receptor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CCT2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For CCT2 there are:
7 structures (68 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CCT2 has been screened with compounds ( bioactivities). (see details)