Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Ubash3a (Q3V3E1) - Overview - Molecular Target Synopsis

Protein


Ubash3a, Ubiquitin-associated and SH3 domain-containing protein A
UniProt Q3V3E1

Also Known as UBS3A_MOUSE, Ubash3a

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain (By similarity). Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. Homodimer or homooligomer. Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins. Interacts with dynamin.

3D4I
CRYSTAL STRUCTURE OF THE 2H-PHOSPHATASE DOMAIN OF STS-2
RCSB/PDB
Inspect Structure
See all 3D Structures for Ubash3a

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
624Q3V3E1-1

Sub-cellular localization


UniProt: Ubash3a is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: Ubash3a is active in the following subcellular-locations: Golgi apparatus, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Ubash3a has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Ubash3a there are:
3 structures (12 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis