Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARL13B (Q3SXY8) - Overview - Molecular Target Synopsis

Protein


ARL13B, ADP-ribosylation factor-like protein 13B
UniProt Q3SXY8

Also Known as AR13B_HUMAN, ARL13B, ARL2L1

Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidences are required to confirm these data. Monomer (By similarity). Interacts with PIFO. Interacts with IFT complex B components IFT46 and IFT74.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ARL13B is active in the following subcellular-locations: cell projection, cilium, cilium membrane.
GO terms: ARL13B is active in the following subcellular-locations: axoneme, ciliary membrane, cilium, motile cilium, non-motile cilium.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARL13B has gain in 6 cell-lines, loss in 1 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MDA_N, OVCAR_8, NCI_ADR_RES

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, HCC12, NCI-H1155

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, SK-N-SH, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to ARL13B there are:
55 structures (130 chains) solved
44 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ARL13B has been screened with compounds ( bioactivities). (see details)