ARL13B (Q3SXY8) - Overview - Molecular Target Synopsis
ARL13B, ADP-ribosylation factor-like protein 13B
Also Known as AR13B_HUMAN, ARL13B, ARL2L1
Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. May regulate endocytic recycling traffic; however, additional evidences are required to confirm these data. Monomer (By similarity). Interacts with PIFO. Interacts with IFT complex B components IFT46 and IFT74.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|428||ENSG00000169379||ENST00000471138, ENST00000394222||ENSP00000420780, ENSP00000377769||Q3SXY8-1|
UniProt: ARL13B is active in the following subcellular-locations: cell projection, cilium, cilium membrane.
GO terms: ARL13B is active in the following subcellular-locations: axoneme, ciliary membrane, cilium, motile cilium, non-motile cilium.