Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

TFB5 (Q3E7C1) - Overview - Molecular Target Synopsis

Protein


TFB5, General transcription and DNA repair factor IIH subunit TFB5
UniProt Q3E7C1

Also Known as TFB5_YEAST, TFB5

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription. TFB5 is required for stable recruitment of TFIIH to a promoter, but not for stability of TFIIH subunits. Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription (PubMed:15220919). Interacts with TFB2 (PubMed:19172752).

6GYM
STRUCTURE OF A YEAST CLOSED COMPLEX WITH DISTORTED DNA (CCDIST)
RCSB/PDB
Inspect Structure
See all 3D Structures for TFB5

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
72Q3E7C1-1

Sub-cellular localization


UniProt: TFB5 is active in the following subcellular-locations: nucleus.
GO terms: TFB5 is active in the following subcellular-locations: cytosol, nucleus, transcription factor TFIID complex, transcription factor TFIIH core complex, transcription factor TFIIH holo complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TFB5 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For TFB5 there are:
7 structures (8 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis