Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LRRK1 (Q38SD2) - Overview - Molecular Target Synopsis

Protein


LRRK1, Leucine-rich repeat serine/threonine-protein kinase 1
Enzyme Classification 2.7.11.1
UniProt Q38SD2

Also Known as LRRK1_HUMAN, LRRK1, KIAA1790

Homodimer.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: LRRK1 is active in the following subcellular-locations: cytoplasm.
GO terms: LRRK1 is active in the following subcellular-locations: cytosol, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LRRK1 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H226, M14, EKVX

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MKN-7, LS 180, SW 1990

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, H1-hESC, GM12878

(see details)

RNA Interference


LRRK1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: AC295, MCF12A. (see details)


Screening and Chemistry


LRRK1 has been screened with compounds ( bioactivities). (see details)