Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

43 (Q38087) - Overview - Molecular Target Synopsis

Protein


43, DNA-directed DNA polymerase
Enzyme Classification 2.7.7.7
UniProt Q38087

Also Known as DPOL_BPR69, 43

Replicates the viral genomic DNA. This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction for proofreading purpose. Part of the replicase complex that includes the DNA polymerase, the polymerase clamp, the clamp loader complex, the single-stranded DNA binding protein, and the primase/helicase (By similarity). Interacts with the polymerase clamp; this interaction constitutes the polymerase holoenzyme (PubMed:10535734).

5GNQ
CRYSTAL STRUCTURE OF REPLISOMAL DIMER OF DNA POLYMERASE FROM BACTERIOPHAGE RB69 WITH DNA DUPLEXES
RCSB/PDB
Inspect Structure
See all 3D Structures for 43

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
903Q38087-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project 43 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For 43 there are:
121 structures (168 chains) solved
105 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

43 is solved in complex with the approved drug(s):

PPF/FOSCARNET (3KD5_E).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


43 has been screened with compounds ( bioactivities). (see details)