Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TRMT5 (Q32P41) - Overview - Molecular Target Synopsis

Protein


TRMT5, tRNA (guanine(37)-N1)-methyltransferase
Enzyme Classification 2.1.1.228
UniProt Q32P41

Also Known as TRM5_HUMAN, TRMT5, KIAA1393, TRM5

Involved in mitochondrial tRNA methylation (PubMed:26189817). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. Monomer.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TRMT5 is active in the following subcellular-locations: cytoplasm, mitochondrion matrix, nucleus.
GO terms: TRMT5 is active in the following subcellular-locations: cytoplasm, mitochondrial matrix, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TRMT5 has gain in 4 cell-lines, loss in 1 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SR, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KARPAS-422, SCC-3, EBC-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: AG445, MCF-7, SK-N-SH

(see details)