TRMT5 (Q32P41) - Overview - Molecular Target Synopsis
TRMT5, tRNA (guanine(37)-N1)-methyltransferase
Enzyme Classification 18.104.22.168
Also Known as TRM5_HUMAN, TRMT5, KIAA1393, TRM5
Involved in mitochondrial tRNA methylation (PubMed:26189817). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. Monomer.
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UniProt: TRMT5 is active in the following subcellular-locations: cytoplasm, mitochondrion matrix, nucleus.
GO terms: TRMT5 is active in the following subcellular-locations: cytoplasm, mitochondrial matrix, nucleus.