Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

P3H1 (Q32P28) - Overview - Molecular Target Synopsis

Protein


P3H1, Prolyl 3-hydroxylase 1
Enzyme Classification 1.14.11.7
UniProt Q32P28

Also Known as P3H1_HUMAN, P3H1, GROS1, LEPRE1

Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: P3H1 is active in the following subcellular-locations: endoplasmic reticulum, extracellular matrix, extracellular space, secreted.
GO terms: P3H1 is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum, endoplasmic reticulum lumen, extracellular exosome, membrane, nucleus, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project P3H1 has gain in 4 cell-lines, loss in 1 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: THP-1, SF539, M059K

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, BJ

(see details)