Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ureA2 (Q2YQE0) - Overview - Molecular Target Synopsis

Protein


ureA2, Urease subunit gamma 2
Enzyme Classification 3.5.1.5
UniProt Q2YQE0

Also Known as URE32_BRUA2, ureA2

Disrupting the ure2 operon has no effect on urease activity or pathogen survival in BALB/c mice when administered orally. Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

4FUR
CRYSTAL STRUCTURE OF UREASE SUBUNIT GAMMA 2 FROM BRUCELLA MELITENSIS BIOVAR ABORTUS 2308
RCSB/PDB
Inspect Structure
See all 3D Structures for ureA2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: ureA2 is active in the following subcellular-locations: cytoplasm.
GO terms: ureA2 is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ureA2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ureA2 there are:
1 structures (6 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ureA2 has been screened with compounds ( bioactivities). (see details)