Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ddb2 (Q2YDS1) - Overview - Molecular Target Synopsis

Protein


ddb2, DNA damage-binding protein 2
UniProt Q2YDS1

Also Known as DDB2_DANRE, ddb2

Required for DNA repair. Binds to ddb1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex which may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. Component of the UV-DDB complex which includes ddb1 and ddb2 (PubMed:19109893). Component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex that includes cul4a, or cul4b, ddb1, ddb2 and rbx1 (PubMed:22118460). A large number of other DCX complexes may also exist in which an alternate substrate targeting subunit replaces ddb2. These targeting subunits are generally known as DCAF (ddb1- and cul4-associated factor) or CDW (cul4-ddb1-associated WD40-repeat) proteins.

4A0K
STRUCTURE OF DDB1-DDB2-CUL4A-RBX1 BOUND TO A 12 BP ABASIC SITE CONTAINING DNA-DUPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for ddb2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
499Q2YDS1-2
496Q2YDS1-1

Sub-cellular localization


UniProt: ddb2 is active in the following subcellular-locations: nucleus.
GO terms: ddb2 is active in the following subcellular-locations: Cul4B-RING E3 ubiquitin ligase complex, nucleoplasm, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ddb2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ddb2 there are:
9 structures (11 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ddb2 has been screened with compounds ( bioactivities). (see details)