ddb2, DNA damage-binding protein 2
Also Known as
Required for DNA repair. Binds to ddb1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex which may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. Component of the UV-DDB complex which includes ddb1 and ddb2 (PubMed:19109893). Component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex that includes cul4a, or cul4b, ddb1, ddb2 and rbx1 (PubMed:22118460). A large number of other DCX complexes may also exist in which an alternate substrate targeting subunit replaces ddb2. These targeting subunits are generally known as DCAF (ddb1- and cul4-associated factor) or CDW (cul4-ddb1-associated WD40-repeat) proteins.