Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ATG2A (Q2TAZ0) - Overview - Molecular Target Synopsis

Protein


ATG2A, Autophagy-related protein 2 homolog A
UniProt Q2TAZ0

Also Known as ATG2A_HUMAN, ATG2A, KIAA0404

Involved in autophagosome assembly, regulating the size of nascent autophagosomes (PubMed:28561066). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). Interacts with WDR45.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ATG2A is active in the following subcellular-locations: lipid droplet, preautophagosomal structure membrane.
GO terms: ATG2A is active in the following subcellular-locations: cytosol, extrinsic component of membrane, intracellular membrane-bounded organelle, lipid droplet, nucleus, phagophore assembly site, phagophore assembly site membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ATG2A has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MDA_MB_231, NCI_ADR_RES, HOP_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: PE01, BICR 31, DEOC-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HUVEC

(see details)