Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SGSM1 (Q2NKQ1) - Overview - Molecular Target Synopsis

Protein


SGSM1, Small G protein signaling modulator 1
UniProt Q2NKQ1

Also Known as SGSM1_HUMAN, SGSM1, KIAA1941, RUTBC2

Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B. Interacts with RAB9A (GTP-bound form) and RAB9B (GTP-bound form); has much lower affinity for GDP-bound RAB9A and RAB9B (PubMed:22637480). Interacts with RAB3A, RAB4A, RAB5A, RAB8A, RAB11A, RAP1A, RAP1B, RAP2A and RAP2B. No interaction with RAB27A (PubMed:17509819).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1165Q2NKQ1-3
1148ENSG00000167037ENST00000400359ENSP00000383212Q2NKQ1-1
1093ENSG00000167037ENST00000400358ENSP00000383211Q2NKQ1-4

Sub-cellular localization


UniProt: SGSM1 is active in the following subcellular-locations: cytoplasm, cytoplasmic vesicle membrane, golgi apparatus, trans-golgi network.
GO terms: SGSM1 is active in the following subcellular-locations: cytoplasm, cytoplasmic vesicle membrane, cytosol, Golgi apparatus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SGSM1 has gain in 5 cell-lines, loss in 2 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: ACHN, MOLT_4, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 454, BEN, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 90% identity similarity to SGSM1 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis