SGSM1 (Q2NKQ1) - Overview - Molecular Target Synopsis
SGSM1, Small G protein signaling modulator 1
Also Known as SGSM1_HUMAN, SGSM1, KIAA1941, RUTBC2
Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B. Interacts with RAB9A (GTP-bound form) and RAB9B (GTP-bound form); has much lower affinity for GDP-bound RAB9A and RAB9B (PubMed:22637480). Interacts with RAB3A, RAB4A, RAB5A, RAB8A, RAB11A, RAP1A, RAP1B, RAP2A and RAP2B. No interaction with RAB27A (PubMed:17509819).
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UniProt: SGSM1 is active in the following subcellular-locations: cytoplasm, cytoplasmic vesicle membrane, golgi apparatus, trans-golgi network.
GO terms: SGSM1 is active in the following subcellular-locations: cytoplasm, cytoplasmic vesicle membrane, cytosol, Golgi apparatus.