Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
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Phactr1 (Q2M3X8) - Overview - Molecular Target Synopsis

Protein


Phactr1, Phosphatase and actin regulator 1
UniProt Q2M3X8

Also Known as PHAR1_MOUSE, Phactr1

Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers. Plays a role in the formation of tubules by endothelial cells. Regulates PPP1CA activity. Required for normal cell survival (By similarity). Plays a role in cell motility. Interacts (via RPEL repeats) with ACTA1 and PPP1CA; ACTA1 and PPP1CA compete for the same binding site.

4B1U
STRUCTURE OF THE PHACTR1 RPEL DOMAIN AND RPEL MOTIF DIRECTED ASSEMBLIES WITH G-ACTIN REVEAL THE MOLECULAR BASIS FOR ACTIN BINDING COOPERATIVITY.
RCSB/PDB
Inspect Structure
See all 3D Structures for Phactr1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
649Q2M3X8-4
642Q2M3X8-3
580Q2M3X8-1
573Q2M3X8-2

Sub-cellular localization


UniProt: Phactr1 is active in the following subcellular-locations: cell junction, cytoplasm, nucleus, synapse.
GO terms: Phactr1 is active in the following subcellular-locations: cell junction, cytosol, nucleus, synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Phactr1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Phactr1 there are:
6 structures (8 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis