Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ABCB5 (Q2M3G0) - Overview - Molecular Target Synopsis


ABCB5, ATP-binding cassette sub-family B member 5
UniProt Q2M3G0

Also Known as ABCB5_HUMAN, ABCB5

Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: ABCB5 is active in the following subcellular-locations: cell membrane.
GO terms: ABCB5 is active in the following subcellular-locations: integral component of plasma membrane, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ABCB5 has gain in 8 cell-lines, loss in 1 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: UACC_257, MDA_MB_435, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: UACC-257, SK23, COLO 741

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 50% identity similarity to ABCB5 there are:
28 structures (39 chains) solved
13 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

ABCB5 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

ABCB5 has been screened with 4 compounds (4 bioactivities). (see details)