Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCB5 (Q2M3G0) - Overview - Molecular Target Synopsis

Protein


ABCB5, ATP-binding cassette sub-family B member 5
UniProt Q2M3G0

Also Known as ABCB5_HUMAN, ABCB5

Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ABCB5 is active in the following subcellular-locations: cell membrane.
GO terms: ABCB5 is active in the following subcellular-locations: integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCB5 has gain in 8 cell-lines, loss in 1 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: UACC_257, MDA_MB_435, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: UACC-257, SK23, COLO 741

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to ABCB5 there are:
28 structures (39 chains) solved
13 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

ABCB5 is solved in complex with the approved drug(s):

CLR/CHOLESTEROL (6QEE_A, 6QEX_A),
TA1/PACLITAXEL (6QEX_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCB5 has been screened with 4 compounds (4 bioactivities). (see details)