Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

alpha-Man-IIa (Q24451) - Overview - Molecular Target Synopsis

Protein


alpha-Man-IIa, Alpha-mannosidase 2
Enzyme Classification 3.2.1.114
UniProt Q24451

Also Known as MAN2_DROME, alpha-Man-IIa, GmII

Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. Homodimer; disulfide-linked.

3EJQ
GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH 5-SUBSTITUED SWAINSONINE ANALOG: (5R)-5-[2'-OXO-2'-(4-METHYLPHENYL)ETHYL]-SWAINSONINE
RCSB/PDB
Inspect Structure
See all 3D Structures for alpha-Man-IIa

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1108Q24451-1

Sub-cellular localization


UniProt: alpha-Man-IIa is active in the following subcellular-locations: golgi apparatus membrane.
GO terms: alpha-Man-IIa is active in the following subcellular-locations: endoplasmic reticulum, Golgi membrane, Golgi stack, integral component of membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project alpha-Man-IIa has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For alpha-Man-IIa there are:
57 structures (57 chains) solved
57 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


alpha-Man-IIa has been screened with compounds ( bioactivities). (see details)