Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GEN1 (Q17RS7) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed2
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria2


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5T9J_B Flap endonuclease GEN homolog 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 58.6 49 Yes No
2 empty 2.04 61.2 35.2 No No
3 bound 2.41 67.6 26.3 No No
4 empty 2.01 64.6 25.7 No No
5 empty 1.91 56.7 17.4 No No
6 empty 1.88 68.1 17.3 No No
7 empty 2.28 66.2 14.5 No No
8 empty 1.87 61.7 12.8 No No
9 empty 2.22 50.5 15.5 No No
10 empty 2.22 53.2 17 No No
5T9J_A Flap endonuclease GEN homolog 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 57.5 40.6 Yes No
2 bound 2.18 64.5 32.3 No No
3 empty 2.36 62.2 30.4 No No
4 empty 1.67 71.3 19.9 No No
5 bound 2.17 69.3 16.2 No No
6 empty 2.14 64.3 21.7 No No
7 empty 1.79 72 13.1 No No
8 empty 2.06 63.2 15.7 No No
9 empty 2.11 54.9 16.9 No No
10 empty 2.22 67.6 11.4 No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score