Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PNLIPRP3 (Q17RR3) - Overview - Molecular Target Synopsis

Protein


PNLIPRP3, Pancreatic lipase-related protein 3
Enzyme Classification 3.1.1.3
UniProt Q17RR3

Also Known as LIPR3_HUMAN, PNLIPRP3

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
467ENSG00000203837ENST00000369230ENSP00000358232Q17RR3-1

Sub-cellular localization


UniProt: PNLIPRP3 is active in the following subcellular-locations: secreted.
GO terms: PNLIPRP3 is active in the following subcellular-locations: extracellular space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PNLIPRP3 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MCF 10A, SUM 229PE, MeWo

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, NHEK, SK-N-SH

(see details)

3D Structures


At greater than 35% identity similarity to PNLIPRP3 there are:
12 structures (16 chains) solved
7 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PNLIPRP3 has been screened with compounds ( bioactivities). (see details)