Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TATDN3 (Q17R31) - Overview - Molecular Target Synopsis

Protein


TATDN3, Putative deoxyribonuclease TATDN3
Enzyme Classification 3.1.21.-
UniProt Q17R31

Also Known as TATD3_HUMAN, TATDN3

Putative deoxyribonuclease.

2Y1H
CRYSTAL STRUCTURE OF THE HUMAN TATD-DOMAIN PROTEIN 3 (TATDN3)
RCSB/PDB
Inspect Structure
See all 3D Structures for TATDN3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TATDN3 is active in the following subcellular-locations: nucleus.
GO terms: TATDN3 is active in the following subcellular-locations: nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TATDN3 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, T47D, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KYSE-150, OCI-AML2, SKM-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, SK-N-SH, A549

(see details)

3D Structures


For TATDN3 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis