Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTA3 (Q16772) - Overview - Molecular Target Synopsis

Protein


GSTA3, Glutathione S-transferase A3
Enzyme Classification 2.5.1.18
UniProt Q16772

Also Known as GSTA3_HUMAN, GSTA3

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. Homodimer.

2VCV
GLUTATHIONE TRANSFERASE A3-3 IN COMPLEX WITH GLUTATHIONE AND DELTA-4- ANDROSTENE-3-17-DIONE
RCSB/PDB
Inspect Structure
See all 3D Structures for GSTA3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: GSTA3 is active in the following subcellular-locations: cytoplasm.
GO terms: GSTA3 is active in the following subcellular-locations: cytosol, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTA3 has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, HOP_92

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-361, HCC2688, COLO 699

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For GSTA3 there are:
2 structures (18 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GSTA3 has been screened with 3 compounds (3 bioactivities). (see details)