Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AMHR2 (Q16671) - Overview - Molecular Target Synopsis

Protein


AMHR2, Anti-Muellerian hormone type-2 receptor
Enzyme Classification 2.7.11.30
UniProt Q16671

Also Known as AMHR2_HUMAN, AMHR2, AMHR, MISR2

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: AMHR2 is active in the following subcellular-locations: membrane.
GO terms: AMHR2 is active in the following subcellular-locations: integral component of plasma membrane, plasma membrane, receptor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AMHR2 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: LOXIMVI, SK_MEL_5, NCI_H522

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEL, K-562, OCI-M1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, NHLF

(see details)

RNA Interference


AMHR2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: H358, HCC70. (see details)

3D Structures


At greater than 35% identity similarity to AMHR2 there are:
1 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


AMHR2 has been screened with compounds ( bioactivities). (see details)