Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
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Gene Copy Number Variation
RNAi
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Germline Genetics

PRSS8 (Q16651) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed10
Chains with at least one site assessed as druggable using the strict criteria3
Chains with at least one site assessed as druggable using the relaxed criteria10


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3GYM_A Prostasin Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 70.4 42.2 Yes No
2 empty 2.12 61 35.8 No No
3 empty 2.31 67.3 21.5 No No
4 empty 2.29 60.4 20.2 No No
5 empty 2.56 65.7 15.4 No No
6 empty 1.88 61.6 16.5 No No
7 empty 2.37 63.7 18.6 No No
8 empty 1.86 71.5 13 No No
9 empty 2.12 69.4 10.4 No No
10 empty 2.32 60.8 15.3 No No
3DFL_A Prostasin Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.08 67.5 47.9 Yes Yes
2 empty 2.22 64 26.6 No No
3 empty 2.44 62.4 18.3 No No
4 empty 1.96 59.9 14.5 No No
5 empty 1.94 61.3 13.9 No No
6 empty 2.38 61.8 25.6 No No
7 empty 2.33 65.1 14.6 No No
8 empty 2.13 68.5 8.8 No No
9 empty 2 68.5 11.1 No No
10 empty 2.57 75.6 8.8 No No
3GYL_B Prostasin Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 69.7 41.1 Yes Yes
2 bound 1.99 62.1 27 No No
3 bound 2.47 65.5 18.1 No No
4 empty 1.84 61.7 15.3 No No
5 empty 2.84 67.5 15.2 No No
6 empty 1.98 65.3 17.5 No No
7 empty 2.26 64.3 14.5 No No
8 empty 2.1 60.4 9.6 No No
9 empty 2.16 57.6 9.4 No No
10 empty 2.75 67.3 11.7 No No
3E1X_B Prostasin Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 66.2 46.2 Yes Yes
2 empty 2.38 65.4 20 No No
3 bound 1.99 65 23.8 No No
4 empty 2.28 66.5 16.1 No No
5 empty 1.84 60.4 14.7 No No
6 empty 2.49 66.2 14.7 No No
7 empty 2.09 67.9 9.7 No No
8 empty 2.18 68.3 9.5 No No
9 empty 2.49 74.1 8.4 No No
10 empty 2.74 58.9 9.6 No No
3E0P_B Prostasin Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 67.4 44.4 Yes No
2 empty 2.21 65.1 35.5 No No
3 empty 2.35 66.2 21.4 No No
4 empty 2.04 60.4 17.7 No No
5 empty 1.84 59.8 14.7 No No
6 empty 2.27 54.9 11 No No
7 empty 2.65 58.7 14.2 No No
8 empty 2 70.9 10.7 No No
9 empty 2.12 68.2 10.1 No No
10 empty 2.17 67.3 10 No No
3E0N_B Prostasin Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 66.2 32.1 Yes No
2 bound 2.28 66.5 22.7 No No
3 bound 2.22 64.9 28.2 No No
4 empty 2.33 70.8 12.9 No No
5 bound 2.3 62.5 22.9 No No
6 empty 2.11 63.5 14.2 No No
7 empty 2.58 61 18.6 No No
8 empty 2.15 66.3 13.1 No No
9 empty 2.26 61.1 14.1 No No
10 empty 1.98 68 9.9 No No
3E16_B Prostasin Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 62.8 43.6 Yes No
2 bound 2.12 66.6 30.9 No No
3 empty 2.27 65.5 22 No No
4 empty 1.74 56.3 16 No No
5 empty 2.43 58 11.4 No No
6 empty 2.1 57.4 10.9 No No
7 empty 2.46 73.1 7.8 No No
8 empty 1.92 61.8 10 No No
9 empty 2.6 63.4 9.3 No No
10 empty 2.71 55.9 10.2 No No
3DFJ_A Prostasin Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 65.3 33.3 Yes No
2 empty 2.31 67.3 17.5 No No
3 empty 2.29 68.1 17.9 No No
4 empty 2.1 63.1 30.6 No No
5 empty 2.31 60.9 22.4 No No
6 empty 2.4 60.6 19 No No
7 empty 1.89 60.6 14.9 No No
8 empty 2.06 63.3 15.3 No No
9 empty 2.16 68.5 9.8 No No
10 empty 2.38 59.4 13 No No
3FVF_B Prostasin Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 64.4 32.3 Yes No
2 empty 2.07 63.5 25.1 No No
3 empty 2.36 64.2 18.8 No No
4 empty 1.96 66.8 19.3 No No
5 empty 1.99 68.6 11.8 No No
6 empty 1.82 55.9 16.3 No No
7 empty 1.84 64.3 10 No No
8 empty 2.03 61.1 11.8 No No
9 empty 2.09 59.4 10.7 No No
10 empty 2.44 65.2 10.1 No No
3GYM_B Prostasin Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 68.6 49.8 Yes No
2 empty 2.13 61.2 37.2 No No
3 empty 2.33 67.2 21.2 No No
4 empty 2.57 66.8 15.2 No No
5 empty 1.81 60.1 15 No No
6 empty 2.3 56.2 18.2 No No
7 empty 2.32 59 14.6 No No
8 empty 1.83 70.5 11.8 No No
9 empty 2.19 64.6 12.7 No No
10 empty 2.21 65.9 10.3 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed9
Domains assessed as druggable using the strict criteria3
Domains assessed as druggable using the relaxed criteria9

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3DFJ_A (3360242) Prostasin Trypsin-like serine proteases, Trypsin-like serine proteases, Eukaryotic proteases 1.45Å Yes No
3DFL_A (3360245) Prostasin Trypsin-like serine proteases, Trypsin-like serine proteases, Eukaryotic proteases 2Å Yes Yes
3E0N_B (3370556) Prostasin Trypsin-like serine proteases, Trypsin-like serine proteases, Eukaryotic proteases 1.7Å Yes No
3E0P_B (3370559) Prostasin Trypsin-like serine proteases, Trypsin-like serine proteases, Eukaryotic proteases 1.7Å Yes No
3E16_B (3370584) Prostasin Trypsin-like serine proteases, Trypsin-like serine proteases, Eukaryotic proteases 1.6Å Yes No
3E1X_B (3370632) Prostasin Trypsin-like serine proteases, Trypsin-like serine proteases, Eukaryotic proteases 1.7Å Yes Yes
3FVF_B (3420066) Prostasin Trypsin-like serine proteases, Trypsin-like serine proteases, Eukaryotic proteases 1.6Å Yes No
3GYL_B (3440728) Prostasin Trypsin-like serine proteases, Trypsin-like serine proteases, Eukaryotic proteases 1.3Å Yes Yes
3GYM_A (3440729) Prostasin Trypsin-like serine proteases, Trypsin-like serine proteases, Eukaryotic proteases 2.8Å Yes No
Ligand-based Druggability Score: -0.9
Ligand-based Druggability Score Percentile: 70%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


PRSS8 is involved in 1 interactions in the network.


Druggability
Overall Druggability Percentile: 15.05
Druggability for Cancer Therapeutics: 9.22
Druggability for Other Therapeutics: 8.56
Cancer-Associated
Cancer-associated percentile : 27.49
Network Articulation Point
Is PRSS8 critical for communication in the network?


Detailed Graph Legend:Help