Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PRSS8 (Q16651) - Overview - Molecular Target Synopsis

Protein


PRSS8, Prostasin
Enzyme Classification 3.4.21.-
UniProt Q16651

Also Known as PRSS8_HUMAN, PRSS8

Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). Heterodimer of two chains, light and heavy, held by a disulfide bond.

3E0N
THE X-RAY STRUCTURE OF HUMAN PROSTASIN IN COMPLEX WITH DFFR- CHLOROMETHYL KETONE INHIBITOR
RCSB/PDB
Inspect Structure
See all 3D Structures for PRSS8

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PRSS8 is active in the following subcellular-locations: cell membrane, extracellular space, secreted.
GO terms: PRSS8 is active in the following subcellular-locations: anchored component of plasma membrane, extracellular exosome, extracellular region, extracellular space, extrinsic component of plasma membrane, integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PRSS8 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H322M, OVCAR_4, HCC_2998

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC2935, C2BBe1, H322T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, NHEK, MCF-7

(see details)

3D Structures


For PRSS8 there are:
9 structures (10 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PRSS8 has been screened with 25 compounds (25 bioactivities), 15 compounds have bioactivities that show binding affinity of <= 500nM (15 bioactivities). (see details)