Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SRSF7 (Q16629) - Overview - Molecular Target Synopsis

Protein


SRSF7, Serine/arginine-rich splicing factor 7
UniProt Q16629

Also Known as SRSF7_HUMAN, SRSF7, SFRS7

Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific. Found in large molecular weight complexes containing CCNL1 and the p110 isoforms of either CDC2L1 or CDC2L2. Interacts with CCNL2 and CPSF6. Interacts with NXF1.

2HVZ
SOLUTION STRUCTURE OF THE RRM DOMAIN OF SR RICH FACTOR 9G8
RCSB/PDB
Inspect Structure
See all 3D Structures for SRSF7

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SRSF7 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: SRSF7 is active in the following subcellular-locations: cytoplasm, extracellular exosome, nuclear speck, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SRSF7 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: TK, SR-786, SK-N-DZ

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, K562

(see details)

3D Structures


For SRSF7 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SRSF7 has been screened with compounds ( bioactivities). (see details)