AANAT (Q16613) - Overview - Molecular Target Synopsis
AANAT, Serotonin N-acetyltransferase
Enzyme Classification 126.96.36.199
Also Known as SNAT_HUMAN, AANAT, SNAT
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. Monomer (By similarity). Interacts with several 14-3-3 proteins, including YWHAB, YWHAE, YWHAG and YWHAZ, preferentially when phosphorylated at Thr-31. Phosphorylation on Ser-205 also allows binding to YWHAZ, but with lower affinity. The interaction with YWHAZ considerably increases affinity for arylalkylamines and acetyl-CoA and protects the enzyme from dephosphorylation and proteasomal degradation (By similarity). It may also prevent thiol-dependent inactivation.
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UniProt: AANAT is active in the following subcellular-locations: cytoplasm.
GO terms: AANAT is active in the following subcellular-locations: cytoplasm, cytosol, perinuclear region of cytoplasm.