Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

AANAT (Q16613) - Overview - Molecular Target Synopsis


AANAT, Serotonin N-acetyltransferase
Enzyme Classification
UniProt Q16613


Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. Monomer (By similarity). Interacts with several 14-3-3 proteins, including YWHAB, YWHAE, YWHAG and YWHAZ, preferentially when phosphorylated at Thr-31. Phosphorylation on Ser-205 also allows binding to YWHAZ, but with lower affinity. The interaction with YWHAZ considerably increases affinity for arylalkylamines and acetyl-CoA and protects the enzyme from dephosphorylation and proteasomal degradation (By similarity). It may also prevent thiol-dependent inactivation.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: AANAT is active in the following subcellular-locations: cytoplasm.
GO terms: AANAT is active in the following subcellular-locations: cytoplasm, cytosol, perinuclear region of cytoplasm.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project AANAT has gain in 6 cell-lines, loss in 0 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: LOXIMVI, NCI_H522, OVCAR_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO-704, NCI-H209, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 75% identity similarity to AANAT there are:
7 structures (11 chains) solved
6 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

AANAT has been screened with compounds ( bioactivities). (see details)