Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

BAK1 (Q16611) - Overview - Molecular Target Synopsis

Protein


BAK1, Bcl-2 homologous antagonist/killer
UniProt Q16611

Also Known as BAK_HUMAN, BAK1, BAK, BCL2L7, CDN1

Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases. Homodimer. Formation of the homodimer is zinc-dependent (PubMed:17157251). Forms heterodimers with BCL2 and BCL2L1 isoform Bcl-X(L) (PubMed:9020082). Forms heterooligomers with BAX (PubMed:29531808). Interacts with BCL2A1 (By similarity). Interacts with RTL10/BOP (PubMed:23055042). Interacts with VDAC1 (PubMed:25296756).

5VX1
BAK L100A
RCSB/PDB
Inspect Structure
See all 3D Structures for BAK1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
211ENSG00000030110ENST00000360661, ENST00000374467ENSP00000353878, ENSP00000363591Q16611-1
153ENSG00000030110ENST00000442998ENSP00000391258Q16611-2

Sub-cellular localization


UniProt: BAK1 is active in the following subcellular-locations: mitochondrion outer membrane.
GO terms: BAK1 is active in the following subcellular-locations: BAK complex, cytosol, endoplasmic reticulum, integral component of mitochondrial outer membrane, mitochondrial outer membrane, mitochondrion, pore complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project BAK1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, HCC_2998, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: BICR 22, NCI-H596, A-431

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, SK-N-SH, NHEK

(see details)

3D Structures


For BAK1 there are:
25 structures (40 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


BAK1 has been screened with 4 compounds (4 bioactivities). (see details)