Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC18A3 (Q16572) - Overview - Molecular Target Synopsis

Protein


SLC18A3, Vesicular acetylcholine transporter
UniProt Q16572

Also Known as VACHT_HUMAN, SLC18A3, VACHT

Involved in acetylcholine transport into synaptic vesicles. Interacts with SEC14L1.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
664ENSG00000187714ENST00000374115ENSP00000363229
532Q16572-1

Sub-cellular localization


UniProt: SLC18A3 is active in the following subcellular-locations: membrane.
GO terms: SLC18A3 is active in the following subcellular-locations: AP-1 adaptor complex, AP-2 adaptor complex, clathrin-coated vesicle membrane, clathrin-sculpted acetylcholine transport vesicle membrane, integral component of membrane, plasma membrane, terminal bouton.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC18A3 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H226, MCF7, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-FI, NCI-H1155, NCI-H2452

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


SLC18A3 has been screened with 241 compounds (268 bioactivities), 154 compounds have bioactivities that show binding affinity of <= 500nM (178 bioactivities). (see details)