Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PCSK7 (Q16549) - Overview - Molecular Target Synopsis

Protein


PCSK7, Proprotein convertase subtilisin/kexin type 7
Enzyme Classification 3.4.21.-
UniProt Q16549

Also Known as PCSK7_HUMAN, PCSK7, LPC, PC7, PC8, SPC7

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PCSK7 is active in the following subcellular-locations: golgi apparatus, trans-golgi network membrane.
GO terms: PCSK7 is active in the following subcellular-locations: integral component of Golgi membrane, membrane, trans-Golgi network.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PCSK7 has gain in 1 cell-lines, loss in 5 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MOLT_4, HS578T, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G130, Hs 255.T, M059K

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, HeLa-S3

(see details)

3D Structures


At greater than 35% identity similarity to PCSK7 there are:
24 structures (50 chains) solved
6 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PCSK7 has been screened with 20 compounds (32 bioactivities), 7 compounds have bioactivities that show binding affinity of <= 500nM (7 bioactivities). (see details)