Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

PCSK7 (Q16549) - Overview - Molecular Target Synopsis


PCSK7, Proprotein convertase subtilisin/kexin type 7
Enzyme Classification 3.4.21.-
UniProt Q16549

Also Known as PCSK7_HUMAN, PCSK7, LPC, PC7, PC8, SPC7

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: PCSK7 is active in the following subcellular-locations: golgi apparatus, trans-golgi network membrane.
GO terms: PCSK7 is active in the following subcellular-locations: integral component of Golgi membrane, membrane, trans-Golgi network.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project PCSK7 has gain in 1 cell-lines, loss in 5 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MOLT_4, HS578T, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G130, Hs 255.T, M059K

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, HeLa-S3

(see details)

3D Structures

At greater than 35% identity similarity to PCSK7 there are:
24 structures (50 chains) solved
6 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

PCSK7 has been screened with 20 compounds (32 bioactivities), 7 compounds have bioactivities that show binding affinity of <= 500nM (7 bioactivities). (see details)