Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

GABRA6 (Q16445) - Overview - Molecular Target Synopsis


GABRA6, Gamma-aminobutyric acid receptor subunit alpha-6
UniProt Q16445

Also Known as GBRA6_HUMAN, GABRA6

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

Isoforms / Transcripts (Protein Coding)


GABRA6 is targeted by Approved Drugs Ethchlorvynol, Clobazam, Eszopiclone. (see details)

Sub-cellular localization

UniProt: GABRA6 is active in the following subcellular-locations: cell junction, cell membrane, postsynaptic cell membrane, synapse.
GO terms: GABRA6 is active in the following subcellular-locations: cell junction, cerebellar Golgi cell to granule cell synapse, chloride channel complex, dendrite membrane, GABA-A receptor complex, integral component of plasma membrane, neuron projection, plasma membrane, postsynapse, postsynaptic membrane, synapse.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project GABRA6 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H209, LN-18, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 50% identity similarity to GABRA6 there are:
16 structures (40 chains) solved
13 are solved in complex with at least one small molecule ligand
4 are solved with an approved drug

GABRA6 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

GABRA6 has been screened with 927 compounds (1399 bioactivities), 338 compounds have bioactivities that show binding affinity of <= 500nM (490 bioactivities). (see details)