Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB11B (Q15907) - Overview - Molecular Target Synopsis

Protein


RAB11B, Ras-related protein Rab-11B
UniProt Q15907

Also Known as RB11B_HUMAN, RAB11B, YPT3

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. Interacts with KCNMA1 (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4 (PubMed:11495908). May interact with TBC1D14 (PubMed:22613832). Interacts with ATP6V1E1 (PubMed:20717956). Interacts with PI4KB (PubMed:23572552). Interacts (GDP-bound form) with ZFYVE27. Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701). Interacts with RELCH.

4OJK
STRUCTURE OF THE CGMP DEPENDENT PROTEIN KINASE II AND RAB11B COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB11B

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB11B is active in the following subcellular-locations: cytoplasmic vesicle, phagosome membrane, recycling endosome membrane, secretory vesicle, synaptic vesicle membrane.
GO terms: RAB11B is active in the following subcellular-locations: anchored component of synaptic vesicle membrane, cell junction, cytosol, endosome, extracellular exosome, phagocytic vesicle, phagocytic vesicle membrane, recycling endosome, recycling endosome membrane, synaptic vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB11B has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_4, DU_145, NCI_H522

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HN, SK-N-FI, KP4

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, IMR-90

(see details)

3D Structures


For RAB11B there are:
3 structures (4 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB11B has been screened with compounds ( bioactivities). (see details)