Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CHRNA6 (Q15825) - Overview - Molecular Target Synopsis

Protein


CHRNA6, Neuronal acetylcholine receptor subunit alpha-6
UniProt Q15825

Also Known as ACHA6_HUMAN, CHRNA6

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Interacts with LYPD6 (PubMed:27344019).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CHRNA6 is active in the following subcellular-locations: cell junction, cell membrane, postsynaptic cell membrane, synapse.
GO terms: CHRNA6 is active in the following subcellular-locations: acetylcholine-gated channel complex, cell junction, dopaminergic synapse, integral component of plasma membrane, integral component of postsynaptic membrane, integral component of presynaptic membrane, neuron projection, plasma membrane, synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CHRNA6 has gain in 7 cell-lines, loss in 5 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CAKI_1, RPMI_8226, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KARPAS-1106P, NCI-H1437, MC116

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 75% identity similarity to CHRNA6 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CHRNA6 has been screened with 14 compounds (30 bioactivities), 13 compounds have bioactivities that show binding affinity of <= 500nM (19 bioactivities). (see details)