Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SPEG (Q15772) - Overview - Molecular Target Synopsis

Protein


SPEG, Striated muscle preferentially expressed protein kinase
Enzyme Classification 2.7.11.1
UniProt Q15772

Also Known as SPEG_HUMAN, SPEG, APEG1, KIAA1297

Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. Interacts with MTM1. Isoform 3 is found as a monomer or homodimer.

1U2H
X-RAY STRUCTURE OF THE N-TERMINALLY TRUNCATED HUMAN APEP-1
RCSB/PDB
Inspect Structure
See all 3D Structures for SPEG

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SPEG is active in the following subcellular-locations: nucleus.
GO terms: SPEG is active in the following subcellular-locations: nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SPEG has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H226, HOP_92, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-387, NCI-H226, G130

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, IMR-90, NHLF

(see details)

RNA Interference


SPEG was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CAL120, CROE33. (see details)

3D Structures


For SPEG there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SPEG has been screened with compounds ( bioactivities). (see details)