Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB30 (Q15771) - Overview - Molecular Target Synopsis

Protein


RAB30, Ras-related protein Rab-30
UniProt Q15771

Also Known as RAB30_HUMAN, RAB30

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins.

2EW1
CRYSTAL STRUCTURE OF RAB30 IN COMPLEX WITH A GTP ANALOGUE
RCSB/PDB
Inspect Structure
See all 3D Structures for RAB30

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB30 is active in the following subcellular-locations: cytoplasm, golgi apparatus, membrane, trans-golgi network.
GO terms: RAB30 is active in the following subcellular-locations: cis-Golgi network, endoplasmic reticulum membrane, Golgi cisterna, Golgi membrane, Golgi stack, intracellular membrane-bounded organelle, trans-Golgi network.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB30 has gain in 7 cell-lines, loss in 1 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, NCI_H522, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1500, DMS 53, MOLP-2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HFDPC

(see details)

3D Structures


For RAB30 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB30 has been screened with compounds ( bioactivities). (see details)