Molecular Target Synopsis
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MAPRE1 (Q15691) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed71
Chains with at least one site assessed as druggable using the strict criteria8
Chains with at least one site assessed as druggable using the relaxed criteria36


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4XA6_D Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 51.2 14.3 No No
2 empty 1.47 68.6 8.6 No No
3 empty 2.07 45.8 10.6 No No
4 empty 2.18 57.1 11.6 No No
5 empty 1.87 62.2 9.7 No No
6 empty 2.11 53.6 13.8 No No
7 empty .62 62 9.8 No No
8 empty 2.33 57.5 10.3 No No
9 empty 2.66 58.2 12 No No
10 empty 2.09 50.7 9.4 No No
2HKQ_A Microtubule-associated protein RP/EB family member 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 53.8 18.5 No No
2 empty 2.61 80.9 8.1 Yes Yes
3 empty 2.28 52.2 12.1 No No
4 empty 1.83 44.4 6.5 No No
5 empty 2.65 61 5.6 No No
6 empty 2.32 58.3 6.4 No No
7 empty 2.02 60.2 5.4 No No
8 empty 3.14 64.4 7 No No
9 empty 3.24 64.6 0 No No
10 empty 1.55 46.4 6.3 No No
5JVP_F Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.65 57.5 26 Yes No
2 empty 2.18 53.2 16.9 No No
3 empty 1.52 69 11 No No
4 empty 2.13 58.9 11.5 No No
5 empty 1.6 53.9 10.8 No No
6 empty 2.06 53.4 10.4 No No
7 empty 1.13 60.3 6.8 No No
8 empty 2.52 65.6 6 No No
9 empty 2.31 46.5 7.5 No No
10 empty 2.82 60.4 9.3 No No
5JV3_C Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.49 73.6 16.1 Yes No
2 empty 2.25 56.1 17.1 No No
3 empty 1.66 61.3 13.5 No No
4 empty 2.21 52.7 10.1 No No
5 empty 2.07 48.6 9.2 No No
6 empty 1.14 45.9 9 No No
7 empty 2.38 61.6 7 No No
8 empty 1.77 46 6.8 No No
9 empty 1.95 48 6.6 No No
10 empty 2.86 57 8.1 No No
1VKA_B Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 63.8 26.9 Yes No
2 empty 2.26 63.8 19 No No
3 empty 1.85 55.6 17 No No
4 empty 2.15 57.3 11.8 No No
5 empty 2.66 61.9 13.6 No No
6 empty 2.2 69.2 12.5 No No
7 empty 2.08 64.4 14 No No
8 empty 1.87 60.3 8.7 No No
9 empty 2.73 83 7.8 No No
10 empty 2.46 66 7.1 No No
5N74_E Microtubule-associated protein RP/EB family member 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.67 60.7 16 No No
2 empty 2.7 80.9 9.5 Yes Yes
3 empty 2.61 56.2 6.2 No No
4 empty 2.25 62.5 8.4 No No
5 empty 2.49 60.3 6.2 No No
6 empty 2.45 66.1 6.5 No No
7 empty 2.16 50.9 6 No No
8 empty .86 73.6 0 No No
9 empty .03 67.1 5.6 No No
10 empty 2.5 62.1 4.7 No No
4XA3_A Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.63 65.8 24.2 Yes No
2 empty 1.75 60.9 19 No No
3 empty 2.7 56.8 11.9 No No
4 empty 1.71 62.5 13.8 No No
5 empty 2.57 62.8 14 No No
6 empty 1.97 64.2 6.9 No No
7 empty 1.31 46.8 7 No No
8 empty 2.29 46.8 8.8 No No
9 empty 2.54 54.2 9.2 No No
10 empty 2.48 56.2 9.2 No No
3MTU_A Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.24 64 21.2 No No
2 bound 2 52.2 20.4 No No
3 empty 2.03 61.5 10.7 No No
4 empty 2.39 52.1 14.3 No No
5 empty 2.22 56.7 10.6 No No
6 empty 1.76 66.2 6.9 No No
7 empty 2.67 59.8 8.9 No No
8 empty 2.76 53.8 7.7 No No
9 empty 2.29 61.6 7.5 No No
10 bound 2.76 56.8 5.8 No No
1YIG_A Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.42 64.2 24 Yes No
2 empty 1.9 58.8 16.6 No No
3 empty 2.37 47.9 9.1 No No
4 empty 2.38 54.7 9.1 No No
5 empty 2.57 51.9 7.5 No No
6 empty .67 79.8 4.9 No No
7 empty 2.37 59.4 5.1 No No
8 empty 0 76.8 5.3 No No
9 empty .29 50 6 No No
10 empty 3.07 55.1 5.1 No No
5N74_C Microtubule-associated protein RP/EB family member 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.4 61.5 17.5 No No
2 empty 2.57 79.4 11.8 Yes Yes
3 empty 2.17 57.7 6.7 No No
4 empty 2.22 56.8 9.8 No No
5 empty 2.4 56.1 6.3 No No
6 empty 2.27 56.2 7 No No
7 empty 1.89 67.2 6.4 No No
8 empty 2.01 53.9 7.9 No No
9 empty 2.52 67.1 5.3 No No
5N74_A Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 58.9 16.8 No No
2 empty 2.62 77.2 9.5 No No
3 empty 2.29 58.5 8.5 No No
4 empty 2.35 58.5 6.8 No No
5 empty 2.47 58.3 6.2 No No
6 empty 2.4 59 5.5 No No
7 empty .69 71.7 5.8 No No
8 empty 2.29 59.8 6.3 No No
9 empty .3 67.4 6.1 No No
10 empty 2.74 63.4 6.3 No No
2HL5_A Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.73 50.1 16 No No
2 empty 2.53 76.9 14.8 No No
3 empty 1.99 52.1 13.8 No No
4 empty .6 40.2 7.2 No No
5 empty 2.61 49 5.9 No No
6 empty 2.05 58.6 5.2 No No
7 empty 2.74 62.1 5.7 No No
8 empty 2.37 60.9 7.9 No No
9 empty 2.5 51.5 5.9 No No
10 empty .74 70.9 5.1 No No
5JV3_D Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 54.2 26.9 Yes No
2 empty 1.71 55.8 17.3 No No
3 empty 2.73 76.9 11 No No
4 empty 2.1 56.9 11.9 No No
5 empty 1.85 56.5 12.1 No No
6 empty 2.14 49.4 8.1 No No
7 empty 2.11 50.9 9.5 No No
8 empty 2.15 58.4 7.3 No No
9 empty 2.18 57 5.1 No No
10 empty 1.6 51.4 6.8 No No
2R8U_A Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 65.9 23.1 No No
2 empty 2.31 65.8 23.6 No No
3 empty 2.32 56.5 20.4 No No
4 empty 1.75 59.8 15.7 No No
5 empty 2.53 63.8 19.1 No No
6 empty 2.24 66.9 12.4 No No
7 empty 1.85 64.8 13.6 No No
8 empty 2.03 59 13.7 No No
9 empty 2.08 55.2 10.1 No No
10 empty 2.68 48.1 8.6 No No
4XA6_C Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.87 66.1 13.2 No No
2 empty 2.45 74 13.6 No No
3 empty 2.66 63.3 13.5 No No
4 empty 1.7 59.2 11.2 No No
5 empty 1.96 54.4 9.1 No No
6 empty 2.52 62.5 11.3 No No
7 empty 1.04 51.3 11.1 No No
8 empty 2.12 61 11.7 No No
9 empty 1.77 48.1 8.3 No No
10 empty 2.38 50 9.3 No No
5N74_F Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.55 73.1 12.5 Yes No
2 empty 1.72 68.3 10.7 No No
3 empty 2.37 54.3 11.3 No No
4 empty 2.46 60.6 11.4 No No
5 empty 2.34 66.9 6 No No
6 empty 2.08 51.8 11.5 No No
7 empty 1.18 45.4 7.8 No No
8 empty .63 65.1 8.9 No No
9 empty 2.15 59.2 7.9 No No
10 empty 3.02 61 6.1 No No
5JVM_A Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 57 31.2 Yes No
2 empty 2.79 73.2 11.1 No No
3 empty 2.11 55 12 No No
4 empty 2.51 56.5 10.3 No No
5 empty 1.88 51.7 12.6 No No
6 empty 2.27 53.8 10.7 No No
7 empty 2.26 57.4 8.2 No No
8 empty 2.04 66.4 5.3 No No
9 empty 3.16 69.9 7.9 No No
10 empty 1.95 53.2 6 No No
1PA7_A Microtubule-associated protein RP/EB family member 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.25 69.2 21.7 Yes Yes
2 bound 2.38 66.1 23.6 No No
3 empty 2.19 59.1 20 No No
4 empty 1.79 57.2 14.8 No No
5 empty 2.36 59.1 18.4 No No
6 empty 2.16 63.3 14.6 No No
7 empty 2.73 61.9 9.9 No No
8 empty 2.18 53.6 8.4 No No
9 empty 2.12 59.4 9.5 No No
10 empty 2.21 68.2 7.1 No No
5JV3_B Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.92 53.6 24.1 Yes No
2 empty 2.7 70.9 13.9 No No
3 empty .61 55.6 13.1 No No
4 empty 2.05 51.2 6.7 No No
5 empty 2.31 65.7 9.2 No No
6 empty 1.73 58.5 5.5 No No
7 empty 2.07 50.9 6.4 No No
8 empty 2.62 59.1 7.7 No No
9 empty 2.12 58.9 6.2 No No
10 empty 2.31 63.5 3.4 No No
4XA1_C Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 55.5 16.7 No No
2 empty 1.89 55.7 13.3 No No
3 empty 2.49 73 9.4 No No
4 empty 2.45 60.3 10.7 No No
5 empty 2.49 77.6 9.7 No No
6 empty 2.46 54.5 11.1 No No
7 empty 2.44 49.5 9.2 No No
8 empty 2.3 55.1 9.8 No No
9 empty 2.72 52.6 9.3 No No
10 empty 1.76 50.9 11.1 No No
3GJO_D Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.76 62.2 12.6 No No
2 empty 2.49 54.5 15 No No
3 empty .48 62.4 12.4 No No
4 empty 2.34 71 11.3 No No
5 empty 2.36 56.9 8.9 No No
6 empty 3 71.6 6.5 No No
7 empty 2.3 67.1 5.5 No No
8 empty 2.8 64.9 5.4 No No
9 empty 2.13 54.9 5.8 No No
10 empty 2.64 49.4 5.3 No No
4XA1_B Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 58.5 21.8 No No
2 empty 1.84 59.1 24 No No
3 empty 2.16 58.9 16.6 No No
4 empty 2.78 71.8 10.9 No No
5 empty 2.25 60 12.3 No No
6 empty 2.27 53.1 9.5 No No
7 empty 2.66 61.7 10.7 No No
8 empty 2.16 55.9 8.2 No No
9 empty .64 51.9 9.3 No No
10 empty 2.49 53.4 7.3 No No
1VKA_A Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 63.7 28.6 Yes No
2 empty 2.44 66 20.7 No No
3 empty 2 55.6 15.3 No No
4 empty 2.51 59.9 17.4 No No
5 empty 2.27 75.7 17.5 No No
6 empty 2.02 66.7 8.5 No No
7 empty 2.55 66.4 11.7 No No
8 empty 2.29 66.3 8.7 No No
9 empty 2.31 60.4 7.1 No No
10 empty 2.64 67.8 5.5 No No
1WU9_A Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 59.9 17.6 No No
2 empty 2.63 73 18.8 No No
3 empty 2.87 60 10.3 No No
4 empty 2.07 56.9 7.2 No No
5 empty 3.13 59 9.3 No No
6 empty .59 41.9 7.9 No No
7 empty 2.11 52.2 5.9 No No
8 empty 2.75 52.3 7 No No
9 empty 2.47 60 7 No No
10 empty 2.32 63.6 5.9 No No
3MTU_C Microtubule-associated protein RP/EB family member 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.77 58.2 18.6 No No
2 bound 2.55 81.3 11.3 Yes Yes
3 empty 2.53 50.4 13 No No
4 empty 1.72 54.3 9.1 No No
5 empty 2.74 54.8 7.8 No No
6 empty 2.51 54.9 10.7 No No
7 empty 2.07 61.4 9.6 No No
8 empty 2.24 67.6 6.5 No No
9 empty .36 54.1 8.2 No No
10 empty 2.12 47.8 6.6 No No
1TXQ_B Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 53.8 16.1 No No
2 empty 2.51 77.3 11.5 No No
3 empty 2.24 49.1 12.5 No No
4 empty 2.07 41.5 8.1 No No
5 empty 2.9 66.4 6.3 No No
6 empty .67 54.4 6.8 No No
7 empty 2.05 51.2 8.7 No No
8 empty 1.94 55.8 6.8 No No
9 empty 2.66 55.9 6 No No
10 empty 2.65 64.6 0 No No
5WLQ_A Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 63.3 18.4 No No
2 empty 1.75 52.5 11.7 No No
3 empty 2.61 53 9.8 No No
4 empty 2.46 58.9 9.7 No No
5 bound 2.06 61.7 7.6 No No
6 empty 2.5 53.6 12.6 No No
7 empty 2.57 67.2 6.9 No No
8 empty 1.89 52.7 8.4 No No
9 empty 2.13 61.8 7.7 No No
10 empty 1.87 66.1 9.4 No No
4XA1_D Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.56 72.5 11.5 Yes No
2 empty 1.82 68.6 10.5 No No
3 empty .71 21.1 9.4 No No
4 empty 2.75 59.1 9.7 No No
5 empty 2.22 65 13.3 No No
6 empty 2.2 60.5 9.8 No No
7 empty 2.92 55.9 10.8 No No
8 empty 1.27 63.6 8.3 No No
9 empty 2.19 48.1 7.5 No No
10 empty 2.12 54.7 7.2 No No
5JVP_A Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 58.6 35.7 Yes No
2 empty 2.22 54 20.4 No No
3 empty 2.21 52.6 11.7 No No
4 empty 2.21 60.2 8.7 No No
5 empty 2.6 55.1 8.8 No No
6 empty 2.58 70.7 8.3 No No
7 empty .55 58.3 6.8 No No
8 empty 2.92 50.4 7.1 No No
9 empty 2.21 60.9 6.9 No No
10 empty 1.1 55.3 7.2 No No
5JVR_B Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.48 55.7 23.4 No No
2 empty 2.72 72.5 9.6 No No
3 empty 2.71 61.6 9.8 No No
4 empty 2.43 57.9 12.3 No No
5 empty 2.71 53 10.5 No No
6 empty 2.29 50.7 8.6 No No
7 empty 2.42 55.5 7.5 No No
8 empty 2.7 61.4 7 No No
9 empty 2.83 66.7 7.7 No No
10 empty 2.14 52.3 6.5 No No
5N74_H Microtubule-associated protein RP/EB family member 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 62.8 12.2 No No
2 empty 2.72 78.9 9.4 Yes Yes
3 empty .61 56 11.9 No No
4 empty 2.29 60 9.5 No No
5 empty 2.05 47.8 7.8 No No
6 empty .83 66.7 6.3 No No
7 empty 2.31 46.2 6.9 No No
8 empty 2.38 59.6 7.5 No No
9 empty 2.73 60.4 5.2 No No
10 empty 3.34 63.1 5.1 No No
5N74_B Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.5 58.9 15.3 No No
2 empty 2.75 70.7 13.9 No No
3 empty 2.17 49.7 9.9 No No
4 empty 2.5 62.5 7.4 No No
5 empty 2.31 61.7 7.4 No No
6 empty 2.42 52.6 8.1 No No
7 empty 2.78 56.8 6.7 No No
8 empty .68 78.1 0 No No
9 empty 2.47 63.4 7.8 No No
10 empty 2.02 54.5 6.8 No No
5JVM_B Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.62 60.4 18.2 No No
2 empty 2.03 57.6 12.8 No No
3 empty 2.08 61.8 12.5 No No
4 empty 2.32 69.5 11.5 No No
5 empty 2.22 54.5 9.9 No No
6 empty 2.55 63.6 4.6 No No
7 empty 2.06 66.7 7.7 No No
8 empty 2.58 53.7 10 No No
9 empty 2.66 63.4 5.3 No No
10 empty 1.54 62.6 6.6 No No
3MUD_D Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.57 52 12.8 No No
2 empty 2.34 54.3 9.4 No No
3 empty 1.33 52.7 10.5 No No
4 empty 2.34 63.6 8.7 No No
5 empty 2.1 54.7 6.6 No No
6 empty 2.59 56.2 7.7 No No
7 empty 2.77 61.5 6.5 No No
8 empty 2.37 49.5 7.5 No No
9 empty 2.09 58.7 6.6 No No
10 empty 2.78 56.8 5.6 No No
5JX1_A Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.7 54.2 22.9 No No
2 empty 2.4 63 12 No No
3 empty 2.48 57.4 18.2 No No
4 empty 2.27 49.1 12.9 No No
5 empty 2.49 59 9.5 No No
6 empty 2.73 61.7 8.8 No No
7 empty 2.57 56.2 11.9 No No
8 empty .5 75.9 6 No No
9 empty 2.14 55.2 7.7 No No
10 empty 2.45 66.4 7.6 No No
5JVS_A Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.77 76.7 10.8 Yes No
2 empty 2.49 58.8 13.8 No No
3 empty 1.74 63.5 9.7 No No
4 empty 1.1 60.1 9.6 No No
5 empty 2.65 53.3 10.1 No No
6 empty 2.08 49.1 9.1 No No
7 empty 2.39 56.8 9.9 No No
8 empty 1.87 58.9 8.4 No No
9 empty 2.23 51.3 8.1 No No
10 empty 2.34 65.8 5.8 No No
1YIG_B Microtubule-associated protein RP/EB family member 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.59 55.8 19.5 No No
2 empty 2.65 84.8 9.5 Yes Yes
3 empty 2.07 51.1 10.7 No No
4 empty 2.99 69.2 6.9 No No
5 empty 2.31 62.2 9 No No
6 empty 1.38 43.4 6.5 No No
7 empty 2.43 60 5.4 No No
8 empty 2.59 53.7 7.1 No No
9 empty 3.4 56.4 5 No No
10 empty .72 66.2 5 No No
3GJO_B Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.63 62.1 26.7 Yes No
2 empty 2.64 68.2 20.8 No No
3 empty 1.13 57.7 12.6 No No
4 empty 2.24 50 11.3 No No
5 empty 2.04 52.3 7.7 No No
6 empty .26 73.9 5.6 No No
7 empty 2.19 55 5 No No
8 empty 2.21 54.9 6 No No
9 empty 3.46 60.7 6.3 No No
10 empty 2.27 57.9 5.1 No No
4XA6_A Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.5 64.2 25.2 Yes No
2 empty 1.69 60.8 26 No No
3 empty 2.12 58.7 14.4 No No
4 empty 1.21 51.4 11.9 No No
5 empty 1.31 48.1 10.6 No No
6 empty 2.63 58.6 12 No No
7 empty 1.81 51.1 10.3 No No
8 empty 2 65.2 9.9 No No
9 empty 2.33 55.6 8.9 No No
10 empty 2.42 70.2 8.5 No No
2QJZ_A Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 67.3 25.6 Yes No
2 empty 2.49 59.9 15.1 No No
3 empty 2 59.2 15.7 No No
4 empty 2.59 60.9 21.6 No No
5 empty 2.26 61.1 16.9 No No
6 empty 2 65.9 13.2 No No
7 empty 2.41 55.8 17.3 No No
8 empty 2.62 71.7 12.3 No No
9 empty 2.61 63.3 12.4 No No
10 empty 2.43 63.7 9 No No
3GJO_C Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.71 62.5 26.5 Yes No
2 empty 2.64 74 9.4 No No
3 empty .68 49.7 9.3 No No
4 empty 2.18 52.5 8.4 No No
5 empty .68 70.2 8.7 No No
6 empty 2.25 54.5 6.1 No No
7 empty 2.01 61.2 5.6 No No
8 empty .88 73.4 5.7 No No
9 empty 2.64 57.9 5.1 No No
10 empty 2.87 47.6 6.3 No No
2HL5_B Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 56.4 20.3 No No
2 empty 2.57 73.5 12.1 No No
3 empty 2.46 56.9 13 No No
4 empty 2.23 52.7 12 No No
5 empty 2.3 60.8 10.4 No No
6 empty .44 69.2 6.2 No No
7 empty 2.47 48.9 5.7 No No
8 empty 2.59 64.9 6.4 No No
9 empty 2.07 56.2 5.2 No No
10 empty 2.94 63 4.7 No No
4XA6_B Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.42 54.3 19.5 No No
2 empty 1.72 57.1 14.5 No No
3 empty 1.77 65.9 8.2 No No
4 empty 1.37 47.4 10.1 No No
5 empty 1.88 57.4 12.2 No No
6 empty 1.46 57.7 12.4 No No
7 empty 2.05 61 10.9 No No
8 empty 2.51 69.5 10.6 No No
9 empty 2.05 61.4 10.2 No No
10 empty 1.52 52.7 10.8 No No
3GJO_A Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.71 59.5 27.7 Yes No
2 empty 2.65 78.2 11.3 No No
3 empty .62 61.1 7.7 No No
4 empty 2.18 59.5 8.5 No No
5 empty 2 47 8.1 No No
6 empty 2.8 57.3 6.7 No No
7 empty 2.21 60 5.8 No No
8 empty 2.62 72.6 4.5 No No
5JVU_B Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 61.6 15.3 No No
2 empty 2.5 73.6 13.9 No No
3 empty 2.16 59.7 14.7 No No
4 empty 1.92 43.5 9.1 No No
5 empty 2.93 57.1 9.9 No No
6 empty 2.26 56 9 No No
7 empty 2.87 53 10.7 No No
8 empty 2.69 58.6 6.7 No No
9 empty 2.22 49.2 7.6 No No
10 empty .56 48.8 6.5 No No
3MUD_C Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 56.7 14.9 No No
2 empty 1.26 58 9.5 No No
3 empty 2.27 53.4 9.9 No No
4 empty 2.78 54.8 7.4 No No
5 empty 2.95 53.6 8.5 No No
6 empty 2.73 54.5 7.4 No No
7 empty 2.3 48.5 6.8 No No
8 empty 2.8 59 7 No No
9 empty 2.37 56.2 6.7 No No
10 empty 1.57 69.2 4.9 No No
1WU9_B Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.53 65.7 23.5 No No
2 empty 1.97 61.6 17.7 No No
3 empty 2.28 54.2 13.5 No No
4 empty 1.14 59.7 10.7 No No
5 empty 2.03 56.5 11.2 No No
6 empty 2.38 63.2 7.8 No No
7 empty 2.63 60 6.1 No No
8 empty 2.27 55.6 7.4 No No
9 empty 2.65 65.9 5.9 No No
10 empty 0 65.8 5.3 No No
5JVP_D Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.81 59.2 31.4 Yes No
2 empty 2.09 53.3 18.7 No No
3 empty 2.83 71.8 13.5 No No
4 empty 2.35 54.7 9.8 No No
5 empty 2.53 55.3 9.6 No No
6 empty 2.37 58.1 7.9 No No
7 empty 1.45 59.2 8.4 No No
8 empty 2.72 58.5 6.7 No No
9 empty 2.23 63.6 8.7 No No
10 empty 2.01 54 7.3 No No
2QJZ_B Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 63.2 35.7 Yes No
2 bound 2.25 73.2 14.5 No No
3 empty 2.25 62 16 No No
4 empty 2.05 61.8 13.7 No No
5 empty 2.44 62.6 21.8 No No
6 bound 1.17 100 0 Yes No
7 bound 2.03 96.5 0 Yes No
8 empty 2.49 62.6 12.6 No No
9 bound 2.41 71.7 9.9 No No
10 empty 1.98 57.2 10.2 No No
5JVP_E Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.88 59.1 32.6 Yes No
2 empty 2.09 55.5 18.8 No No
3 empty 2.11 45.9 11.9 No No
4 empty 2.32 58 9.4 No No
5 empty .39 66.1 8.8 No No
6 empty 2.51 58.3 8.5 No No
7 empty 2.21 61.3 11.6 No No
8 empty 2.32 57.9 7.4 No No
9 empty 2.05 51.9 7 No No
10 empty 2.54 58.2 5.9 No No
5JVR_F Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.38 71.5 15.7 Yes No
2 empty 1.82 54.5 23.3 No No
3 empty 2.35 52.7 16.2 No No
4 empty 2.53 58.3 11.5 No No
5 empty 2.66 64.1 10.9 No No
6 empty 2.02 54.8 9.3 No No
7 empty 2.55 53.8 7.8 No No
8 empty 2.65 66.2 6.1 No No
9 empty 1.98 52.6 6.4 No No
10 empty .2 69.4 6 No No
4XA3_B Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.74 65.1 19.6 No No
2 empty 2.06 61.5 22.7 No No
3 empty 1.8 63.9 10.6 No No
4 empty 2.61 61.6 12.1 No No
5 empty 2.64 58.9 9.4 No No
6 empty 2.48 68 7.1 No No
7 empty 3.43 71.1 9.6 No No
8 empty 1.2 61.6 8.9 No No
9 empty 2.9 57.1 7.7 No No
10 empty 2.22 53.7 6.9 No No
5JVU_A Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 61.5 30 Yes No
2 empty 2.8 62.4 14.7 No No
3 empty 2.27 55 11.2 No No
4 empty 2.2 53.4 10.2 No No
5 empty 1.13 44 9.2 No No
6 empty 2.59 63.3 9.2 No No
7 empty 3.11 74.2 6.3 No No
8 empty 2.1 56.1 6.7 No No
9 empty 2.73 63.3 8.5 No No
10 empty 2.28 54.1 6.3 No No
3MTU_B Microtubule-associated protein RP/EB family member 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.84 56.1 18.4 No No
2 bound 2.37 79.6 9.1 Yes Yes
3 empty 1.97 52.6 13.2 No No
4 empty 2.64 55.7 11.2 No No
5 empty 2.79 55 8.4 No No
6 empty 1.6 52.3 8.2 No No
7 empty 1.34 48.4 7.6 No No
8 empty 2.19 57.9 6.3 No No
9 empty 2.12 17.6 9.4 No No
10 empty 2.6 58.4 8.2 No No
5N74_G Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.7 58.6 16.8 No No
2 empty 2.7 74.2 10.3 No No
3 empty 2.29 62.5 11.2 No No
4 empty 2.57 63 8.4 No No
5 empty 2.38 61.3 6.8 No No
6 empty 2.51 60.2 5.9 No No
7 empty 2.19 49.5 7.3 No No
8 empty 2.77 55.8 5.7 No No
9 empty 2.68 58.1 5.5 No No
10 empty 0 70.3 5.2 No No
5JVR_D Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 51.3 29.7 Yes No
2 empty 2.74 77.3 10.8 No No
3 empty 2.7 58.9 14.6 No No
4 empty 2.63 55.6 9.1 No No
5 empty 2.3 60.7 12.7 No No
6 empty 2.92 67.5 7.2 No No
7 empty 2.54 53.2 7.5 No No
8 empty .67 72.2 5.3 No No
9 empty 2.16 57.3 8 No No
10 empty 1.95 54.1 6.9 No No
5JV3_A Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 62.7 17.1 No No
2 empty 2.05 63.3 13.6 No No
3 empty 2.08 58.5 12.1 No No
4 empty .54 60.2 11.3 No No
5 empty 2.45 52.9 10 No No
6 empty 1.78 61.3 6.1 No No
7 empty 2.52 65.3 6.7 No No
8 empty 2.84 59.6 8.5 No No
9 empty 1.64 51.5 7.9 No No
10 empty 2.59 60.2 6.5 No No
1UEG_A Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 68.4 18.2 No No
2 empty 2.22 70.8 21.6 No No
3 empty 2.27 60.6 19.9 No No
4 empty 2.21 63.8 23.6 No No
5 empty 1.59 64.1 10.9 No No
6 empty 2.18 67.8 14.2 No No
7 empty 2.73 61.8 15.8 No No
8 empty 1.63 56.8 12 No No
9 empty 2.31 57.6 7.5 No No
10 empty 2.16 44.9 7.9 No No
5JVP_B Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.81 60.8 24.5 Yes No
2 empty 2.58 65.9 21.2 No No
3 empty 2.19 53.6 16 No No
4 empty 2.41 56.5 12.4 No No
5 empty 2.38 53.3 16.2 No No
6 empty 1.67 60.4 9.3 No No
7 empty 2.48 56.6 10.3 No No
8 empty 2.49 58.9 5.5 No No
9 empty 2.86 69.5 5.4 No No
10 empty 1.64 51.5 7.6 No No
5N74_D Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.69 62.1 11 No No
2 empty 2.88 74.8 9.2 No No
3 empty 2.43 53.3 9.5 No No
4 empty .64 76 0 No No
5 empty 2.32 59.2 7.3 No No
6 empty .31 37.7 7.8 No No
7 empty 2.28 55.9 5.5 No No
8 empty 2.45 60 6.2 No No
9 empty .17 70.6 5.5 No No
10 empty 2.48 62.9 5.8 No No
3MTU_D Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 52.1 22.8 No No
2 bound 2.6 77.3 8.8 No No
3 empty 2.53 60 9.1 No No
4 empty 2.33 55.6 10.7 No No
5 empty 2.87 53.1 8 No No
6 empty 1.74 53.8 7.4 No No
7 empty 2.22 54.3 7.4 No No
8 empty 2.85 72.4 0 No No
9 empty 1.59 58.4 5.3 No No
10 empty 2.74 59 6.1 No No
5JVR_E Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.58 57.9 17.5 No No
2 empty 2.54 60.2 16.6 No No
3 empty 2.84 80.5 11.5 No No
4 empty 2.25 56.3 8.5 No No
5 empty 2.45 57.1 6.8 No No
6 empty 2.92 65.3 6.3 No No
7 empty 2.37 62.7 7.9 No No
8 empty 2.99 65 5.3 No No
9 empty 2.14 59.4 5.5 No No
10 empty 2.67 43.7 7.5 No No
5JVR_C Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 54.3 23.9 No No
2 empty 2.35 72.5 15 No No
3 empty 2.3 59.3 14.8 No No
4 empty 2.58 57.6 12.1 No No
5 empty 2.67 63 7.8 No No
6 empty .57 55.3 9.5 No No
7 empty 2.5 56.5 10.3 No No
8 empty 2.98 57.7 7.3 No No
9 empty 2.55 58.8 7.9 No No
10 empty 2.08 39.7 8.4 No No
3TQ7_A Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 45.4 20.6 No No
2 empty 2.24 66.8 12.1 No No
3 empty 1.54 24.4 11.7 No No
4 empty 3.24 48.6 7 No No
5 empty 2.23 57.1 6.7 No No
6 empty 2.16 42 6.5 No No
7 empty 2.51 58.2 6.9 No No
8 empty 2 56.2 5.9 No No
9 empty .64 46.8 7.4 No No
10 empty .64 72.1 5.4 No No
4XA1_A Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.86 57.2 21.5 No No
2 empty 1.63 59.6 16.6 No No
3 empty 2.38 77.7 8.7 No No
4 empty 2.53 55.2 12.4 No No
5 empty 2.49 61 14 No No
6 empty 2.84 56.9 10.7 No No
7 empty 2.21 50.6 10.7 No No
8 empty 2.46 60 9.3 No No
9 empty 2.83 66.4 5.4 No No
10 empty 2.24 44.7 7.3 No No
1YIB_A Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 56.7 18.1 No No
2 empty 2.53 73.5 10.3 No No
3 empty 2.44 54.9 6.2 No No
4 empty 2.84 60.5 6.8 No No
5 empty 1.81 56.7 7.2 No No
6 empty .61 65.4 5.8 No No
7 empty 2.36 63.2 5.7 No No
8 empty 2.5 55.6 7.2 No No
9 empty 2.27 56.4 5.4 No No
10 empty 2.22 46.7 6.4 No No
5JVP_C Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 59.9 31.2 Yes No
2 empty 2.15 53.4 15.4 No No
3 empty 2.85 64.7 9.4 No No
4 empty 2.49 54.3 12.4 No No
5 empty 1.57 55.3 11 No No
6 empty 2 55.7 7.7 No No
7 empty 2.73 56.9 7.8 No No
8 empty 2.21 59.1 7.5 No No
9 empty 2.56 58.8 6 No No
10 empty 2.45 61.1 6.5 No No
5JVR_A Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 51.4 26 Yes No
2 empty 2.48 63.1 13.2 No No
3 empty 2.81 66.7 7.3 No No
4 empty 1.91 61.3 12.6 No No
5 empty 1.84 55.1 8.8 No No
6 empty 2.76 68.2 4.9 No No
7 empty 2.69 51 7.2 No No
8 empty 2.55 69.5 6.4 No No
9 empty 2.93 50.5 6 No No
10 empty 1.71 53.2 5.5 No No
5JVR_G Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.87 53.7 22.5 No No
2 empty 2.39 58.8 12.1 No No
3 empty 2.66 75 8.8 No No
4 empty 2.23 63.3 8.7 No No
5 empty 2.3 48.6 8.2 No No
6 empty 2.13 61.9 6 No No
7 empty 2.43 49.6 8 No No
8 empty .67 69.4 6 No No
9 empty 2.76 60 6.4 No No
10 empty 2.83 61.5 4.6 No No
2R8U_B Microtubule-associated protein RP/EB family member 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 65.1 34 Yes No
2 empty 2.24 63.4 29.3 No No
3 empty 2.65 40.5 16.9 No No
4 empty 1.86 59 12.5 No No
5 empty 2.32 59.2 20.5 No No
6 empty 2.3 58.4 15.7 No No
7 empty 2.08 63.7 12.4 No No
8 empty 1.93 68.8 10 No No
9 empty 2.1 58.6 11.3 No No
10 empty 2.05 62.2 10.8 No No
5JVR_H Microtubule-associated protein RP/EB family member 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 55 18.3 No No
2 empty 2.41 70.1 10.6 No No
3 empty 2.12 53.7 14.1 No No
4 empty 2.49 53.1 16.8 No No
5 empty 2.14 55.2 12.6 No No
6 empty 1.29 51 9.7 No No
7 empty 2.58 58.5 7.4 No No
8 empty 2.87 55.5 5.7 No No
9 empty .72 67 5.3 No No
10 empty 1.96 65.6 6.7 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed20
Domains assessed as druggable using the strict criteria3
Domains assessed as druggable using the relaxed criteria7

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1PA7_A (94410) Microtubule-associated protein RP/EB family member 1 CH domain-like, Calponin-homology domain CH-domain, Calponin-homology domain CH-domain 1.45Å No Yes
1TXQ_B (119389) Microtubule-associated protein RP/EB family member 1 EB1 dimerisation domain-like, EB1 dimerisation domain-like, EB1 dimerisation domain-like 1.8Å No No
1UEG_A (99258) Microtubule-associated protein RP/EB family member 1 CH domain-like, Calponin-homology domain CH-domain, Calponin-homology domain CH-domain 2.4Å No No
1VKA_A (108641) Microtubule-associated protein RP/EB family member 1 CH domain-like, Calponin-homology domain CH-domain, Calponin-homology domain CH-domain 1.6Å Yes No
1VKA_B (108642) Microtubule-associated protein RP/EB family member 1 CH domain-like, Calponin-homology domain CH-domain, Calponin-homology domain CH-domain 1.6Å Yes No
1VKA_A (4108632) Microtubule-associated protein RP/EB family member 1 CH domain-like, Calponin-homology domain CH-domain, Calponin-homology domain CH-domain (Homo Multimer) 1.6Å Yes No
1VKA_B (4108632) Microtubule-associated protein RP/EB family member 1 CH domain-like, Calponin-homology domain CH-domain, Calponin-homology domain CH-domain (Homo Multimer) 1.6Å Yes No
1WU9_A (4181666) Microtubule-associated protein RP/EB family member 1 UNMATCHED, UNMATCHED, UNMATCHED 1WU9 HOMO 1.54Å No No
1WU9_B (4181666) Microtubule-associated protein RP/EB family member 1 UNMATCHED, UNMATCHED, UNMATCHED 1WU9 HOMO 1.54Å No No
1WU9_B (121280) Microtubule-associated protein RP/EB family member 1 EB1 dimerisation domain-like, EB1 dimerisation domain-like, EB1 dimerisation domain-like 1.54Å No No
1WU9_A (121279) Microtubule-associated protein RP/EB family member 1 EB1 dimerisation domain-like, EB1 dimerisation domain-like, EB1 dimerisation domain-like 1.54Å No No
1YIB_A (123278) Microtubule-associated protein RP/EB family member 1 EB1 dimerisation domain-like, EB1 dimerisation domain-like, EB1 dimerisation domain-like 1.8Å No No
1YIG_B (123292) Microtubule-associated protein RP/EB family member 1 EB1 dimerisation domain-like, EB1 dimerisation domain-like, EB1 dimerisation domain-like 2Å No Yes
1YIG_A (4244134) Microtubule-associated protein RP/EB family member 1 P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, YjeE-like 2Å Yes No
1YIG_A (123291) Microtubule-associated protein RP/EB family member 1 EB1 dimerisation domain-like, EB1 dimerisation domain-like, EB1 dimerisation domain-like 2Å Yes No
1YIG_B (4244134) Microtubule-associated protein RP/EB family member 1 P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, YjeE-like 2Å Yes No
2HKQ_A (136557) Microtubule-associated protein RP/EB family member 1 EB1 dimerisation domain-like, EB1 dimerisation domain-like, EB1 dimerisation domain-like 1.86Å No Yes
2HL5_B (136560) Microtubule-associated protein RP/EB family member 1 EB1 dimerisation domain-like, EB1 dimerisation domain-like, EB1 dimerisation domain-like 1.93Å No No
2HL5_A (136559) Microtubule-associated protein RP/EB family member 1 EB1 dimerisation domain-like, EB1 dimerisation domain-like, EB1 dimerisation domain-like 1.93Å No No
2QJZ_A (150835) Microtubule-associated protein RP/EB family member 1 CH domain-like, Calponin-homology domain CH-domain, Calponin-homology domain CH-domain 1.25Å Yes No
2QJZ_B (150836) Microtubule-associated protein RP/EB family member 1 CH domain-like, Calponin-homology domain CH-domain, Calponin-homology domain CH-domain 1.25Å Yes No
2R8U_A (151743) Microtubule-associated protein RP/EB family member 1 CH domain-like, Calponin-homology domain CH-domain, Calponin-homology domain CH-domain 1.35Å No No
2R8U_B (151744) Microtubule-associated protein RP/EB family member 1 CH domain-like, Calponin-homology domain CH-domain, Calponin-homology domain CH-domain 1.35Å No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


MAPRE1 is involved in 28 interactions in the network.


Druggability
Overall Druggability Percentile: 29.02
Druggability for Cancer Therapeutics: 71.15
Druggability for Other Therapeutics: 27.64
Cancer-Associated
Cancer-associated percentile : 77.78
Network Articulation Point
Is MAPRE1 critical for communication in the network?


Detailed Graph Legend:Help