Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TGFBI (Q15582) - Overview - Molecular Target Synopsis

Protein


TGFBI, Transforming growth factor-beta-induced protein ig-h3
UniProt Q15582

Also Known as BGH3_HUMAN, TGFBI, BIGH3

Plays a role in cell adhesion (PubMed:8024701). May play a role in cell-collagen interactions. Binds to type I, II, and IV collagens.

5NV6
STRUCTURE OF HUMAN TRANSFORMING GROWTH FACTOR BETA-INDUCED PROTEIN (TGFBIP).
RCSB/PDB
Inspect Structure
See all 3D Structures for TGFBI

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TGFBI is active in the following subcellular-locations: extracellular matrix, extracellular space, secreted.
GO terms: TGFBI is active in the following subcellular-locations: basement membrane, collagen-containing extracellular matrix, extracellular exosome, extracellular matrix, extracellular region, extracellular space, plasma membrane, trans-Golgi network.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TGFBI has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RXF_393, HS578T, SF_539

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC4006, OVCAR-8, 786-O

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: IMR-90, AG445, HSMM

(see details)

3D Structures


For TGFBI there are:
5 structures (7 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis