Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TESK1 (Q15569) - Overview - Molecular Target Synopsis

Protein


TESK1, Dual specificity testis-specific protein kinase 1
Enzyme Classification 2.7.12.1
UniProt Q15569

Also Known as TESK1_HUMAN, TESK1

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis. Interacts with TAOK2; leading to inhibit TAOK2 activity. Interacts with SPRED1; leading to inhibit activity (By similarity). Interacts with SPRY4.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
626ENSG00000107140ENST00000336395ENSP00000338127Q15569-1

Sub-cellular localization


GO terms: TESK1 is active in the following subcellular-locations: cytoplasm, cytoplasmic vesicle, cytosol, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TESK1 has gain in 4 cell-lines, loss in 3 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_75, SK_OV_3, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCC-9, DOK, MG-63

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, HUVEC

(see details)

RNA Interference


TESK1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SKGT4, HCH1. (see details)

3D Structures


At greater than 35% identity similarity to TESK1 there are:
9 structures (16 chains) solved
9 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TESK1 has been screened with 147 compounds (190 bioactivities), 9 compounds have bioactivities that show binding affinity of <= 500nM (12 bioactivities). (see details)