Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TCEA2 (Q15560) - Overview - Molecular Target Synopsis

Protein


TCEA2, Transcription elongation factor A protein 2
UniProt Q15560

Also Known as TCEA2_HUMAN, TCEA2

Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. Interacts with the basal transcription factor GTF2B. Interacts with REXO1.

2LW4
SOLUTION NMR STRUCTURE OF HUMAN TRANSCRIPTION ELONGATION FACTOR A PROTEIN 2, CENTRAL DOMAIN, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET HR8682B
RCSB/PDB
Inspect Structure
See all 3D Structures for TCEA2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TCEA2 is active in the following subcellular-locations: nucleus.
GO terms: TCEA2 is active in the following subcellular-locations: transcription elongation factor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TCEA2 has gain in 7 cell-lines, loss in 1 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_75, EKVX, NCI_H522

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: PK-59, SK-N-FI, SNU-182

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HUVEC

(see details)

3D Structures


For TCEA2 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TCEA2 has been screened with compounds ( bioactivities). (see details)