Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAPRE2 (Q15555) - Overview - Molecular Target Synopsis

Protein


MAPRE2, Microtubule-associated protein RP/EB family member 2
UniProt Q15555

Also Known as MARE2_HUMAN, MAPRE2, RP1

May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration. Interacts with DCTN1 (PubMed:14514668). Interacts with APC (via C-terminal) (PubMed:9233623, PubMed:14514668). Interacts with monomeric and polymerized tubulin (PubMed:10188731, PubMed:14514668, PubMed:26637975). Interacts with SLAIN1 (PubMed:21646404).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MAPRE2 is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: MAPRE2 is active in the following subcellular-locations: cytoplasm, cytoplasmic microtubule, focal adhesion, microtubule, microtubule cytoskeleton, microtubule organizing center, microtubule plus-end, spindle midzone.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MAPRE2 has gain in 4 cell-lines, loss in 10 cell-lines and no signal in 991 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CCRF_CEM, HS578T, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KARPAS-422, NCI-H209, Hs 578T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, NHLF, BJ

(see details)

3D Structures


At greater than 75% identity similarity to MAPRE2 there are:
10 structures (15 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis