Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MMD (Q15546) - Overview - Molecular Target Synopsis

Protein


MMD, Monocyte to macrophage differentiation factor
UniProt Q15546

Also Known as PAQRB_HUMAN, MMD, PAQR11

Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
238ENSG00000108960ENST00000262065ENSP00000262065Q15546-1
147ENSG00000108960ENST00000571578ENSP00000459202

Sub-cellular localization


UniProt: MMD is active in the following subcellular-locations: late endosome membrane, lysosome membrane.
GO terms: MMD is active in the following subcellular-locations: Golgi apparatus, integral component of plasma membrane, late endosome membrane, lysosomal membrane, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MMD has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_5, TK_10, EKVX

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: PSN1, Hep G2, SK-N-FI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, A549

(see details)