Molecular Target Synopsis
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FCN2 (Q15485) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/04/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/04/2019)


Chains assessed65
Chains with at least one site assessed as druggable using the strict criteria9
Chains with at least one site assessed as druggable using the relaxed criteria43


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2J1G_E Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 67.7 26.7 Yes No
2 bound 2.19 69.3 22.5 No No
3 empty 2.13 70.3 9.6 No No
4 empty 2.52 73.1 10.3 No No
5 bound 1.8 64.4 11.7 No No
6 empty 2.97 61.3 12 No No
7 empty 2.69 73.4 9.7 No No
8 empty 2.61 58.1 11 No No
9 empty 2.04 63.1 7.8 No No
10 empty 2.78 59.5 9.8 No No
2J2P_B Ficolin-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 67.7 29.2 Yes Yes
2 bound 2.1 66.9 28.4 No No
3 empty 2.33 74.9 10.6 No No
4 empty 2 67 9.2 No No
5 empty 2.53 61 14.6 No No
6 empty 2.6 59.2 12.1 No No
7 empty 2.06 71.5 6.9 No No
8 empty 2.82 61.5 8 No No
9 empty 2.16 75.5 8.2 No No
10 empty 2.3 62 13.9 No No
4NYT_C Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 69 20.8 No No
2 empty 2.15 77.1 17.5 No No
3 empty 2.24 61 17.2 No No
4 empty 2.39 69 10 No No
5 empty 2.49 72.3 12.8 No No
6 bound 1.79 65.6 13.7 No No
7 empty 2.18 65.2 8.4 No No
8 empty 1.93 66.9 7.4 No No
9 empty 2.36 61.6 8 No No
10 bound 2.79 57.7 8.8 No No
2J3F_C Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 65.8 24.7 Yes No
2 empty 2.2 63.3 24.6 No No
3 empty 2.33 75.7 19.7 No No
4 empty 2.21 64.1 17.1 No No
5 empty 1.95 64.2 14.9 No No
6 empty 2.38 69.8 11.1 No No
7 empty 2.49 65.3 10.3 No No
8 empty 2.36 60.3 11 No No
9 empty 1.8 62.6 8.9 No No
10 empty 2.81 60.6 9.4 No No
2J3G_B Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 66.8 21.8 No No
2 empty 2.31 63.5 19.5 No No
3 empty 1.86 81 13.7 No No
4 empty 2.49 70.8 9.1 No No
5 empty 2.04 69.1 10 No No
6 empty 2.18 58.7 10.3 No No
7 empty 2.46 58.1 11.3 No No
8 empty 2.23 75.7 7.7 No No
9 empty 2.24 65.1 6.7 No No
10 empty 2.24 65 9 No No
2J1G_F Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.12 64.5 28.1 Yes No
2 empty 2.25 64.3 24.4 No No
3 empty 1.96 72.2 17.1 No No
4 empty 2.42 72.3 9.6 No No
5 bound 2.09 65.4 9.5 No No
6 empty 2.09 62.2 13 No No
7 empty 2.79 61.1 10.2 No No
8 empty 2.2 62.8 7.7 No No
9 empty 2.28 61.7 10.7 No No
10 empty 2.27 77.9 7.8 No No
2J0Y_E Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 68.2 24.1 Yes No
2 empty 2.29 64.6 25.4 No No
3 empty 2.13 73.9 20.8 No No
4 empty 2.58 74.2 9.9 No No
5 empty 1.8 68 11.1 No No
6 empty 2.39 66.4 9.8 No No
7 empty 2.37 59.6 13.7 No No
8 empty 2.16 61.9 7.4 No No
9 empty 1.91 61.4 7.7 No No
10 empty 2.3 59.3 13.1 No No
2J3U_C Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.43 66.9 24.6 Yes No
2 bound 2.15 66.9 22.4 No No
3 empty 2.04 68.3 11.2 No No
4 empty 2.42 72 12.6 No No
5 empty 2.5 57.7 13.8 No No
6 bound 2.04 62.9 10.5 No No
7 empty 2.76 71.6 7.6 No No
8 empty 2.15 65.4 12.9 No No
9 empty 2.59 67.7 6.3 No No
10 empty 1.9 66.5 8.7 No No
2J0Y_A Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 64.6 25.9 Yes No
2 empty 2.45 65.3 17.3 No No
3 empty 2.18 58.8 18.7 No No
4 empty 2.31 63.2 14.2 No No
5 empty 1.76 76.4 12.3 No No
6 empty 2.27 70.9 16.6 No No
7 empty 2.6 79.4 9.9 No No
8 empty 2.35 66.1 13.3 No No
9 empty 1.79 60.2 9.7 No No
10 empty 2.84 70.4 7.6 No No
2J3F_F Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 65.5 25.6 Yes No
2 empty 2.38 75.6 15.5 No No
3 empty 2.08 69.4 13 No No
4 empty 2.12 59.3 18 No No
5 empty 2.36 70 12.7 No No
6 empty 1.96 67.9 8.7 No No
7 empty 2.35 59.9 12.8 No No
8 empty 2.23 65.5 10.1 No No
9 empty 2.29 82.7 7.2 No No
10 empty 1.9 69.9 5.6 No No
2J61_B Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 69.3 24.3 Yes No
2 empty 2.26 64 26.4 No No
3 empty 1.88 63.2 21.9 No No
4 empty 1.84 64 14.1 No No
5 empty 2.63 71.3 8.8 No No
6 empty 2.61 61.8 11.2 No No
7 empty 2.19 59.3 9.7 No No
8 empty 2.35 60.8 9.6 No No
9 empty 2.32 69.7 7 No No
10 empty 1.73 62.4 8.7 No No
2J3U_D Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 64.2 20.3 No No
2 empty 2.34 64.7 16.6 No No
3 empty 2.15 75.5 17.3 No No
4 empty 2.13 65.8 25.2 No No
5 empty 2.47 70.8 11.9 No No
6 empty 2.14 74.4 9.3 No No
7 empty 2.45 58.1 14.6 No No
8 empty 1.75 65 9.3 No No
9 empty 2.51 56.6 8.8 No No
10 empty 2.72 60.7 8.8 No No
2J3O_C Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 72.5 17.2 Yes No
2 empty 2.19 63.3 26.1 No No
3 bound 1.86 63.5 23.8 No No
4 empty 2.65 68.6 9.9 No No
5 empty 2.16 62.9 13.5 No No
6 empty 2.42 65.1 7.7 No No
7 empty 2.3 60 10.8 No No
8 bound 1.84 61.7 9.4 No No
9 empty 2.26 60.6 12.7 No No
10 empty 2.09 75.9 7.6 No No
4R9J_B Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.11 63.6 26.6 Yes No
2 empty 2.15 62.5 17.5 No No
3 empty 2.06 66.3 13.7 No No
4 empty 1.76 81 12.3 No No
5 empty 2.47 76 11.1 No No
6 bound 1.98 66.5 9.4 No No
7 empty 2.6 58.5 13.2 No No
8 empty 2.09 58.5 12 No No
9 empty 2.45 61.6 9.9 No No
10 empty 2.11 55.7 7.9 No No
2J0H_C Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 63.9 25.9 Yes No
2 empty 1.86 64 22.3 No No
3 empty 2.22 68.7 16.9 No No
4 empty 2.53 69.4 10.1 No No
5 empty 2 67.5 9.2 No No
6 empty 2.65 61.9 12.2 No No
7 empty 2.18 57.8 12.3 No No
8 empty 2.08 67.5 6.6 No No
9 empty 1.76 60 8.8 No No
10 empty 2.68 63.8 9.8 No No
4NYT_A Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 65.1 27.4 Yes No
2 empty 2.17 67.8 12.2 No No
3 empty 2.28 60.6 17.3 No No
4 empty 2.4 73.9 10.3 No No
5 empty 2.2 83.1 10.8 No No
6 bound 2.1 64.8 10.4 No No
7 empty 2.59 67.7 8.2 No No
8 empty 1.83 63.8 7.7 No No
9 empty 2.35 57.2 7.7 No No
10 empty 2.29 58.9 9 No No
2J3G_E Ficolin-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.84 65 18 No No
2 empty 1.92 82.8 11.7 Yes Yes
3 empty 2.07 70.4 11.8 No No
4 empty 2.12 60 16.2 No No
5 empty 2.53 72.3 12.4 No No
6 empty 2.59 60.9 19.4 No No
7 empty 1.82 66.7 9.2 No No
8 empty 1.99 61.6 10.2 No No
9 empty 2.28 55.1 8.5 No No
10 empty 2.16 61.8 12.8 No No
2J0G_E Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 65.3 22.3 No No
2 empty 2.27 64.1 26 No No
3 empty 2 72 21.4 No No
4 empty 1.99 68.6 13.9 No No
5 empty 2.62 72.6 9.7 No No
6 empty 2.32 60.4 11.4 No No
7 empty 2.25 61.6 12.9 No No
8 empty 2.28 62.4 9.2 No No
9 empty 1.7 65.1 5 No No
10 empty 1.87 54.3 8.9 No No
2J3U_E Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.17 66.1 25.4 Yes No
2 empty 2.27 68.3 23.9 No No
3 empty 2.06 69.4 11.3 No No
4 empty 2.3 61.3 18.6 No No
5 empty 2.58 68 12.2 No No
6 bound 1.72 67.1 9.1 No No
7 empty 2.66 61.4 12.9 No No
8 bound 2.81 61.2 10.9 No No
9 empty 2.61 58.6 7.5 No No
10 empty 2.39 57.4 9.6 No No
2J0G_C Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 67.1 14.7 No No
2 empty 2.13 73.3 18 No No
3 empty 1.99 66.9 10.2 No No
4 empty 2.01 58.4 18.8 No No
5 empty 2.44 70.6 8.9 No No
6 empty 2.02 62 13.3 No No
7 empty 2.27 68 11.1 No No
8 empty 2.72 63.4 8.5 No No
9 empty 2.55 60.2 10.7 No No
10 empty 2.22 69.8 8.4 No No
2J2P_E Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.1 68.1 28.9 Yes No
2 empty 2.25 64.9 25.8 No No
3 empty 2.21 81.2 13.5 No No
4 empty 2.46 70.4 11.5 No No
5 empty 2 68.2 13.2 No No
6 empty 2.79 59.8 12.1 No No
7 empty 2.44 65.9 9.5 No No
8 empty 1.91 65.4 7.5 No No
9 empty 1.84 62.4 8.9 No No
10 empty 2.42 77.6 7.4 No No
4R9J_A Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 69.2 21.3 No No
2 empty 2.28 60.9 17.3 No No
3 empty 1.97 79.3 12.8 No No
4 empty 2.11 66.3 12.2 No No
5 empty 2.35 70.1 11 No No
6 bound 2.09 65.7 10.5 No No
7 empty 2.02 62.6 12.5 No No
8 empty 2.5 78.3 8 No No
9 empty 2.02 67.9 9.2 No No
10 empty 2.72 59.7 10 No No
2J3U_B Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 66.5 23.2 No No
2 empty 2.36 77 18.9 No No
3 empty 2.35 59.8 19.5 No No
4 empty 2.08 62.5 14.7 No No
5 empty 2.5 70.3 12 No No
6 empty 2.65 60.2 18.9 No No
7 bound 1.7 65.1 8.5 No No
8 empty 2.2 58.8 10.1 No No
9 empty 2.46 63.4 9.6 No No
10 empty 1.9 60.8 9.2 No No
2J3O_A Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 66.2 25.5 Yes No
2 empty 2.38 64.1 25.6 No No
3 empty 2.48 74.5 20.1 No No
4 empty 1.94 65.2 19.4 No No
5 empty 2.35 56.3 14.3 No No
6 empty 2.49 73 9.9 No No
7 empty 2.46 76.2 9.2 No No
8 empty 2.21 57.6 11.6 No No
9 empty 2.15 54.9 8.9 No No
10 empty 1.89 63.6 9.3 No No
2J3F_E Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 64.2 25.3 Yes No
2 bound 1.84 63.8 23.3 No No
3 empty 2.3 75.3 18.9 No No
4 empty 2.73 73.2 8.2 No No
5 empty 2.29 72.2 12 No No
6 empty 1.76 63.2 12.2 No No
7 empty 2.56 62.3 9 No No
8 empty 2.25 64.4 7.2 No No
9 empty 2.28 64.7 11.7 No No
10 empty 2.62 55.4 11.9 No No
4R9T_B Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 66.6 23.3 No No
2 empty 2.26 60 29.2 No No
3 empty 2.23 76.2 18.9 No No
4 empty 2.56 71.7 12 No No
5 bound 1.77 65.3 10.7 No No
6 empty 2.24 60.3 9.4 No No
7 empty 2.5 55.3 11.3 No No
8 empty 2.53 63.4 8.3 No No
9 empty 1.97 64.1 8.9 No No
10 empty 2.42 59.1 8.7 No No
2J0H_F Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 65.9 24.9 Yes No
2 empty 2.25 63.2 24.4 No No
3 empty 1.97 79 13.6 No No
4 empty 2.41 70.4 8.7 No No
5 empty 2.45 69.1 10.8 No No
6 empty 1.99 64.8 11 No No
7 empty 2.63 57.3 9.8 No No
8 empty 2.13 61.7 12.8 No No
9 empty 2.05 65 8.1 No No
10 empty 2.51 61.3 6.6 No No
2J2P_D Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 67.5 22.5 No No
2 empty 2.22 64.5 25.4 No No
3 empty 2.23 74.8 15.8 No No
4 empty 2.46 72.3 10.8 No No
5 empty 2.32 55.7 15.6 No No
6 empty 2.16 68.2 11.1 No No
7 empty 2.64 67.4 10.3 No No
8 empty 2.41 59.5 12.6 No No
9 empty 2.11 58.5 13.3 No No
10 empty 2.6 55.1 8.5 No No
2J0Y_B Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 67.6 23.8 No No
2 empty 2.2 69.4 19.1 No No
3 empty 2.05 54.8 20.2 No No
4 empty 2.17 67.7 15 No No
5 empty 1.93 66.7 18.4 No No
6 empty 2.61 70.7 11.5 No No
7 empty 2.43 58.7 13.4 No No
8 empty 2.34 61.9 9.6 No No
9 empty 2.18 60 9.6 No No
10 empty 2.42 79.5 7.5 No No
2J0H_B Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 66.6 24.8 Yes No
2 empty 2.26 63.7 26 No No
3 empty 2.1 79.1 14.3 No No
4 empty 2.67 74.3 6 No No
5 empty 1.7 63.7 12.2 No No
6 empty 2.58 58.6 16.9 No No
7 empty 2.38 60.6 8.3 No No
8 empty 1.84 62.9 6.3 No No
9 empty 2.42 75.4 7.7 No No
10 empty 1.94 65.3 8 No No
2J3G_D Ficolin-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 75.6 24.4 Yes Yes
2 empty 2.17 65.3 26.5 No No
3 empty 2.33 65 18.9 No No
4 empty 2.55 59.9 13.2 No No
5 empty 1.95 67.1 12.6 No No
6 empty 2.61 73 10.1 No No
7 empty 2.48 62.8 13.9 No No
8 empty 2.77 67.1 9.5 No No
9 empty 2.21 60.1 12.8 No No
10 empty 2.57 62.4 7.6 No No
2J1G_C Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 64.2 21.3 No No
2 empty 2.12 71.8 16.8 No No
3 empty 2.2 62.4 17.5 No No
4 empty 2.11 68.6 14.2 No No
5 empty 2.49 67.9 11.3 No No
6 bound 1.98 63.7 10.1 No No
7 empty 2.2 62.1 10.5 No No
8 empty 1.94 68.5 6.8 No No
9 empty 2.58 60.5 8.5 No No
10 empty 2.88 61.9 9.1 No No
4R9T_A Ficolin-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 66.4 22.6 No No
2 empty 2.36 85.7 13.5 Yes Yes
3 empty 1.79 67.2 13.9 No No
4 empty 2.2 62.4 12.2 No No
5 empty 2.56 63.9 11.5 No No
6 empty 2.33 64.6 10.8 No No
7 empty 2.06 57.9 9.6 No No
8 empty 2.4 56.3 10.2 No No
9 empty 2.67 57.2 8.8 No No
10 empty 2.53 62 6.3 No No
2J1G_D Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 66.8 22.3 No No
2 empty 2.33 63.3 15.2 No No
3 empty 2.21 79.9 12.6 No No
4 empty 2.27 59.6 16.5 No No
5 empty 2.7 74.4 12.7 No No
6 empty 1.93 65.6 8.7 No No
7 empty 2.46 70 8.1 No No
8 empty 2.81 72.5 7.2 No No
9 empty 2.69 64.9 11 No No
10 empty 2.44 63.3 6.8 No No
2J1G_B Ficolin-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.18 66 23 No No
2 empty 2.21 79.2 14.3 Yes Yes
3 empty 2.07 67.1 11.4 No No
4 empty 2.3 56.8 18.4 No No
5 empty 2.67 73.2 8.9 No No
6 bound 1.99 64.7 11.8 No No
7 bound 2.67 57.1 12.3 No No
8 empty 2.42 74.9 8 No No
9 empty 2.07 64.1 8.7 No No
10 empty 2.3 69.6 6.8 No No
2J3U_A Ficolin-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 70.2 21.8 Yes Yes
2 empty 1.93 63.9 20.5 No No
3 empty 2.39 67.3 10.9 No No
4 empty 2.48 71.8 10.5 No No
5 empty 1.77 61 13.3 No No
6 empty 2.46 57.7 13.7 No No
7 empty 2.63 64.3 10.6 No No
8 empty 2.09 52.7 9.7 No No
9 empty 2.27 58.7 10.1 No No
10 empty 2.82 60.3 11.3 No No
2J0G_A Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 64.6 22.8 No No
2 empty 2.1 78.4 14.7 No No
3 empty 2.06 61.2 18.7 No No
4 empty 2.09 66.2 12.9 No No
5 empty 2.52 69.2 9.6 No No
6 empty 1.73 66.4 11.9 No No
7 empty 2.44 65.9 10.4 No No
8 empty 2.34 61.1 8.2 No No
9 empty 2.17 75.8 8.6 No No
10 empty 2.37 56.2 9.4 No No
2J3F_B Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 72.5 23.6 Yes No
2 empty 2.23 65.4 25.9 No No
3 empty 1.88 64 16.7 No No
4 empty 2.51 72.3 12 No No
5 empty 1.91 67.3 12.8 No No
6 empty 2.05 63.8 8.3 No No
7 empty 2.53 62.3 8.9 No No
8 bound 2.73 48.4 13.6 No No
9 empty 2.25 63 13.4 No No
10 empty 1.87 63.2 8.5 No No
2J3O_E Ficolin-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 65.4 19.6 No No
2 empty 1.91 82.9 11.1 Yes Yes
3 empty 2.11 59.4 16.3 No No
4 empty 2.06 71.7 9.2 No No
5 empty 2.49 69.2 11.6 No No
6 empty 1.97 67.3 11 No No
7 empty 2.15 60.6 10.1 No No
8 empty 2.18 78.5 8 No No
9 empty 2.41 66.3 8.4 No No
10 empty 2.61 67 10.9 No No
2J3F_A Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 69.3 22.2 No No
2 empty 2.26 62.7 28.2 No No
3 empty 2.28 67.8 21.7 No No
4 empty 2.27 83.8 13.2 No No
5 empty 2.24 68.9 12.1 No No
6 empty 2.47 71.5 9.3 No No
7 empty 2.63 65 10.9 No No
8 empty 2.42 71.1 7 No No
9 empty 2.17 62.3 13.1 No No
10 empty 2.54 62.1 8.1 No No
4R9J_G Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 65.7 19.9 No No
2 empty 2.14 59 19.4 No No
3 empty 1.97 68.9 13.8 No No
4 empty 2.13 69.1 10.9 No No
5 empty 2.47 64.4 11.6 No No
6 bound 1.66 64 11.2 No No
7 empty 2.27 59.8 8.4 No No
8 empty 2.05 54.4 9.1 No No
9 empty 1.88 57.3 8.9 No No
10 bound 1.85 56.6 6.7 No No
2J2P_F Ficolin-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 68.4 20.3 No No
2 empty 2.47 80.8 13.2 Yes Yes
3 empty 2.27 56.1 21 No No
4 empty 2.23 65.2 15.1 No No
5 empty 2.46 72.3 10.7 No No
6 empty 2.08 66.4 8.9 No No
7 empty 2.53 67.2 14.7 No No
8 empty 2.57 60.5 6.7 No No
9 empty 2.65 81.4 8.3 No No
10 empty 2.71 64.2 9.4 No No
4NYT_B Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 77 15.1 Yes No
2 empty 2.12 65.6 20.1 No No
3 empty 2.07 61.4 16.5 No No
4 empty 2.24 68.5 14.7 No No
5 empty 2.65 72 12 No No
6 empty 1.94 60.7 15.6 No No
7 empty 2.41 61.5 11.1 No No
8 empty 2.35 60.8 7.8 No No
9 empty 2.01 62.4 12.7 No No
10 empty 1.85 65 8.8 No No
2J3G_A Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 65.8 35.9 Yes No
2 empty 1.78 64.3 19.6 No No
3 empty 2.05 69.9 14.6 No No
4 empty 2.7 64.2 16.8 No No
5 empty 2.63 69 12 No No
6 empty 1.98 68 8.7 No No
7 empty 2.49 60.1 11 No No
8 empty 2.08 63.3 9.5 No No
9 empty 1.89 57.2 8.4 No No
10 empty 1.93 70.3 5.4 No No
2J3O_D Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 62.9 25.6 Yes No
2 bound 1.85 64.2 19.1 No No
3 empty 2.07 75.8 15.9 No No
4 empty 2.53 59.6 15 No No
5 empty 2.48 69 10 No No
6 empty 2.06 64.8 13 No No
7 empty 2.04 69.8 8.4 No No
8 empty 2.08 62.7 9.9 No No
9 empty 1.95 63.4 7 No No
10 empty 2.46 57.6 6.7 No No
2J0H_D Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 64.8 28.2 Yes No
2 empty 1.85 62.4 20.4 No No
3 empty 2.42 78.8 13.2 No No
4 empty 1.97 69.5 8.5 No No
5 empty 2.64 70.9 11.3 No No
6 empty 2.41 67.4 9.2 No No
7 empty 2.17 59.7 12.8 No No
8 empty 2.68 69.8 8.1 No No
9 empty 1.8 63.2 8.9 No No
10 empty 2.54 64.5 7.6 No No
2J0Y_C Ficolin-2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 71 19.4 No No
2 empty 2.06 79 11.9 Yes Yes
3 empty 2.1 67.1 10.4 No No
4 empty 2.16 61.7 19.1 No No
5 empty 2.47 75.1 10.2 No No
6 empty 2.06 63.5 12 No No
7 empty 2.53 58.6 14.3 No No
8 empty 2.23 66.3 8.2 No No
9 empty 2.26 60.4 13.4 No No
10 empty 1.82 64.2 8.4 No No
2J3G_F Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.38 62.7 29.3 Yes No
2 empty 2.12 76.8 14.8 No No
3 empty 1.89 64.1 20.2 No No
4 empty 2.47 74.7 10 No No
5 empty 1.95 63.6 11.5 No No
6 empty 2.23 64.5 12.9 No No
7 empty 1.82 66 8.7 No No
8 empty 2.61 63.1 9.2 No No
9 empty 2.47 65.6 7.5 No No
10 empty 1.92 67.7 5.6 No No
2J0Y_D Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 64.7 22.8 No No
2 empty 2.28 61.2 27.8 No No
3 empty 1.98 76.9 11.1 No No
4 empty 2.07 63.6 15.4 No No
5 empty 2.63 71.9 9.9 No No
6 empty 2.3 67.1 10.2 No No
7 empty 2.55 62.8 10.9 No No
8 empty 1.95 59.4 10.1 No No
9 empty 2.28 60.8 12 No No
10 empty 1.81 61.9 8.5 No No
2J2P_A Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 63.5 26.1 Yes No
2 empty 2.05 67.1 21.6 No No
3 empty 2.34 73.7 17.1 No No
4 empty 1.98 68.2 9.1 No No
5 empty 2.48 80.1 9.6 No No
6 empty 2.17 60.8 9.6 No No
7 empty 2.46 60.1 9.5 No No
8 empty 2.65 73.8 8.3 No No
9 empty 2.68 64.9 8.8 No No
10 bound 1.88 64.1 5.9 No No
4R9T_C Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.1 64.3 23.2 No No
2 empty 2.34 78 16 No No
3 empty 1.93 58.9 17.6 No No
4 empty 2.2 70.7 9.7 No No
5 empty 2.41 72 10.4 No No
6 bound 2.03 64.3 10.3 No No
7 empty 2.44 60.1 11.4 No No
8 empty 2.71 70.9 7.8 No No
9 empty 2.52 59.3 12.5 No No
10 empty 2.18 61.7 13.1 No No
2J0G_B Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 67 22 No No
2 empty 2.34 65.2 26 No No
3 empty 2.54 68.2 11.3 No No
4 empty 1.92 67.5 9.9 No No
5 empty 2.53 63.3 9.4 No No
6 empty 2.35 89.9 9.1 Yes No
7 empty 2.26 62.9 9.5 No No
8 empty 2.27 60.8 8.1 No No
9 empty 1.97 61.9 8.8 No No
10 empty 1.88 69.3 6 No No
2J3U_F Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 65.6 23.8 No No
2 empty 2.33 62.2 26.4 No No
3 empty 2.05 73.3 17.7 No No
4 empty 2.42 72.3 12 No No
5 bound 2.14 65.4 10.3 No No
6 empty 2.46 75.7 7.5 No No
7 empty 2.63 60.5 8.5 No No
8 empty 1.98 65.7 5.9 No No
9 empty 2.6 63.4 7.5 No No
10 empty 1.96 59.9 9.1 No No
2J0H_E Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 67.2 26.6 Yes No
2 empty 1.98 69.8 18.9 No No
3 empty 1.95 67.9 11.8 No No
4 empty 1.94 63.1 19.1 No No
5 empty 2.67 55.7 15.6 No No
6 empty 2.75 75.9 12.2 No No
7 empty 2.3 64.4 9.9 No No
8 empty 1.87 62.4 6.2 No No
9 empty 2.24 63.5 11.9 No No
10 empty 2.48 68 7.8 No No
2J1G_A Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 71.4 17.3 Yes No
2 empty 2.19 67.5 17.4 No No
3 empty 2.32 61.4 18.5 No No
4 empty 1.61 75 14.2 No No
5 empty 1.95 64.2 15.2 No No
6 empty 2.23 63 11.5 No No
7 empty 2.67 76.9 11.1 No No
8 empty 2.37 60.4 9.2 No No
9 empty 1.82 60.7 10 No No
10 empty 2.38 85.1 8.7 Yes No
2J61_A Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.37 74.1 21.4 Yes No
2 bound 2.07 61.3 17.9 No No
3 empty 2.28 66.8 16.3 No No
4 empty 2.39 63.6 16.4 No No
5 empty 2.19 62.3 19.7 No No
6 empty 2.41 72.1 11.8 No No
7 empty 1.96 70.6 7.8 No No
8 empty 1.97 61.9 9.1 No No
9 empty 2.28 63 6.2 No No
10 empty 2.33 61.3 8.5 No No
2J0G_F Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 67.1 24.2 Yes No
2 empty 2.21 63.2 27.4 No No
3 empty 2.19 82.7 11.6 No No
4 empty 2.44 70.8 11.2 No No
5 bound 1.99 62.2 10.8 No No
6 empty 2.37 61 12.3 No No
7 empty 2.71 63.2 8.5 No No
8 empty 2.27 76.6 8.1 No No
9 empty 2.6 64.6 8.9 No No
10 empty 1.87 68.2 7.7 No No
2J3O_F Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.35 63.6 25.8 Yes No
2 empty 1.76 62.4 16.1 No No
3 empty 1.99 81.9 13.3 No No
4 empty 1.85 66.1 20.2 No No
5 empty 2.43 64.9 13.8 No No
6 empty 2.49 68.2 11.1 No No
7 empty 2 68.4 7.2 No No
8 empty 2.18 66 10.7 No No
9 empty 2.45 62 10.6 No No
10 empty 1.77 60.5 8.4 No No
2J3G_C Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 67.1 27 Yes No
2 empty 2.38 75 20.2 No No
3 empty 2.41 66.5 18.6 No No
4 empty 2.16 70.2 9.7 No No
5 empty 2.49 75.9 8.7 No No
6 empty 2.06 60.1 9.5 No No
7 empty 2.39 62.1 10 No No
8 empty 2.22 61.4 11 No No
9 empty 1.87 65.1 8.2 No No
10 empty 2.25 57.1 7.6 No No
2J3F_D Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 63.2 27.2 Yes No
2 empty 1.98 65.7 19.9 No No
3 empty 1.91 78.4 17.1 No No
4 empty 2.05 65.3 22.2 No No
5 empty 2.6 69.6 11.1 No No
6 empty 2.22 57.6 17.6 No No
7 empty 2.68 64.3 8.4 No No
8 empty 2.57 59.7 15.2 No No
9 empty 2.26 61.7 12.3 No No
10 empty 2.28 61.7 7.5 No No
2J3O_B Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.38 66.5 17.5 No No
2 bound 1.86 61.5 24.4 No No
3 empty 2 79.8 13.2 No No
4 empty 2.02 67.1 13.6 No No
5 empty 2.5 62.3 11.5 No No
6 bound 1.94 66.2 11.4 No No
7 empty 2.22 67.5 11.6 No No
8 empty 2.5 55.2 12.3 No No
9 empty 2.03 54.1 9.5 No No
10 empty 1.73 58.2 9.8 No No
2J0Y_F Ficolin-2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.37 62.2 27.2 Yes No
2 empty 2.09 65.6 22.4 No No
3 empty 2.01 78.8 11.9 No No
4 empty 2.49 68.4 11 No No
5 empty 2.05 63.6 10.2 No No
6 empty 2.08 62.3 9.7 No No
7 empty 2.42 77.2 7.1 No No
8 empty 2.8 55.9 10.4 No No
9 empty 2.24 59.3 13.3 No No
10 empty 1.87 62.8 8.8 No No
2J0G_D Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 66.7 22.5 No No
2 empty 2.15 62 28.7 No No
3 empty 2.43 77 15.2 No No
4 empty 2.49 72.4 9.1 No No
5 empty 2.12 67.4 9.8 No No
6 empty 2.68 62 11.7 No No
7 empty 2.36 76.1 11.2 No No
8 empty 2.49 61.4 9.8 No No
9 empty 2.24 60.3 12.3 No No
10 empty 2.97 68.9 9.1 No No
2J2P_C Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.02 68.5 18.4 No No
2 empty 2.26 61.9 17.4 No No
3 empty 2.34 79.4 11.8 No No
4 empty 2.06 62 12.8 No No
5 bound 2.09 66.8 11.5 No No
6 empty 2.06 68.6 11.6 No No
7 empty 2.45 60.2 9.1 No No
8 empty 2.49 61.6 14.9 No No
9 empty 2.53 62.7 9.9 No No
10 empty 2.46 58.4 11.9 No No
2J0H_A Ficolin-2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 63 22.6 No No
2 empty 2.21 62.9 27.3 No No
3 empty 2.44 75.7 13.8 No No
4 empty 2.61 69.6 10.6 No No
5 empty 2.04 68.4 9.1 No No
6 empty 2.58 59.8 16.3 No No
7 empty 2.53 69.7 9.8 No No
8 empty 2.31 77.7 8.6 No No
9 empty 1.86 63.9 8.5 No No
10 empty 2.08 59.9 9.1 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed29
Domains assessed as druggable using the strict criteria18
Domains assessed as druggable using the relaxed criteria25

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2J0G_D (4022776) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.8Å Yes Yes
2J0G_E (4022776) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.8Å Yes Yes
2J0G_B (4075657) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.8Å Yes Yes
2J0G_A (3120876) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.8Å No No
2J0G_A (4075657) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.8Å Yes Yes
2J0G_C (4075657) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.8Å Yes Yes
2J0G_F (4022776) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.8Å Yes Yes
2J0H_E (4100915) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.85Å Yes Yes
2J0H_A (4149217) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.85Å Yes Yes
2J0H_B (4149217) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.85Å Yes Yes
2J0H_A (3120877) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.85Å No No
2J0H_D (4100915) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.85Å Yes Yes
2J0H_C (4149217) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.85Å Yes Yes
2J0H_F (4100915) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.85Å Yes Yes
2J0Y_D (4004310) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.35Å Yes Yes
2J0Y_F (4004310) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.35Å Yes Yes
2J0Y_B (4254229) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.35Å Yes Yes
2J0Y_C (4254229) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.35Å Yes Yes
2J0Y_A (4254229) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.35Å Yes Yes
2J0Y_A (3120896) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.35Å Yes No
2J0Y_E (4004310) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.35Å Yes Yes
2J1G_D (4105973) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 1.95Å Yes Yes
2J1G_F (4105973) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 1.95Å Yes Yes
2J1G_A (3120909) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 1.95Å Yes No
2J1G_B (4056955) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 1.95Å Yes Yes
2J1G_C (4056955) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 1.95Å Yes Yes
2J1G_A (4056955) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 1.95Å Yes Yes
2J1G_E (4105973) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 1.95Å Yes Yes
2J2P_A (3120953) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.8Å Yes No
2J2P_D (4261773) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.8Å Yes Yes
2J2P_F (4261773) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.8Å Yes Yes
2J2P_E (4261773) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.8Å Yes Yes
2J2P_A (4148026) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.8Å Yes Yes
2J2P_C (4148026) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.8Å Yes Yes
2J2P_B (4148026) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.8Å Yes Yes
2J3F_B (4066908) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.8Å Yes Yes
2J3F_C (4066908) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.8Å Yes Yes
2J3F_A (4066908) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.8Å Yes Yes
2J3F_A (3120963) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.8Å No No
2J3F_D (3120964) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.8Å Yes No
2J3G_A (3120965) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.5Å Yes No
2J3G_C (4058982) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.5Å Yes Yes
2J3G_B (4058982) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.5Å Yes Yes
2J3G_A (4058982) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.5Å Yes Yes
2J3G_F (4108342) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.5Å Yes Yes
2J3G_D (4108342) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.5Å Yes Yes
2J3G_E (4108342) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.5Å Yes Yes
2J3O_B (4264648) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.65Å Yes Yes
2J3O_C (4264648) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.65Å Yes Yes
2J3O_D (4104664) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.65Å Yes Yes
2J3O_F (4104664) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.65Å Yes Yes
2J3O_A (4264648) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.65Å Yes Yes
2J3O_E (4104664) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.65Å Yes Yes
2J3O_A (3120999) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.65Å Yes No
2J3U_F (4208637) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.15Å Yes Yes
2J3U_C (4035570) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.15Å Yes Yes
2J3U_D (4208637) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.15Å Yes Yes
2J3U_E (4208637) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.15Å Yes Yes
2J3U_A (3130008) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.15Å No Yes
2J3U_A (4035570) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.15Å Yes Yes
2J3U_B (4035570) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like (Homo Multimer) 2.15Å Yes Yes
2J61_A (3130081) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.7Å Yes No
2J61_B (3130082) Ficolin-2 Fibrinogen C-terminal domain-like, Fibrinogen C-terminal domain-like, UNMATCHED 2.7Å Yes No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


FCN2 is involved in 4 interactions in the network.


Druggability
Overall Druggability Percentile: 80.79
Druggability for Cancer Therapeutics: 59.45
Druggability for Other Therapeutics: 75.64
Cancer-Associated
Cancer-associated percentile : 30.12
Network Articulation Point
Is FCN2 critical for communication in the network?


Detailed Graph Legend:Help