Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FCN2 (Q15485) - Overview - Molecular Target Synopsis

Protein


FCN2, Ficolin-2
UniProt Q15485

Also Known as FCN2_HUMAN, FCN2, FCNL

May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region. Homotrimer (PubMed:17215869). Interacts with elastin. Interacts with MASP1 and MASP2. Interacts with CR1.

4R9J
L-FICOLIN COMPLEXED TO GLUCOSAMINE-6-SULFATE
RCSB/PDB
Inspect Structure
See all 3D Structures for FCN2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
313ENSG00000160339ENST00000291744ENSP00000291744Q15485-1
275ENSG00000160339ENST00000350339ENSP00000291741Q15485-2

Sub-cellular localization


UniProt: FCN2 is active in the following subcellular-locations: secreted.
GO terms: FCN2 is active in the following subcellular-locations: blood microparticle, collagen trimer, extracellular exosome, extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FCN2 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1770, YMB-1, SCLC-22H

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For FCN2 there are:
13 structures (65 chains) solved
13 are solved in complex with at least one small molecule ligand
4 are solved with an approved drug

FCN2 is solved in complex with the approved drug(s):

BGC/DEXTROSE (2J0Y_C, 2J0Y_F),
ACH/ACETYLCHOLINE (2J0H_A, 2J0H_B, 2J0H_C, 2J0H_E, 2J0H_F),
SC2/ACETYLCYSTEINE (2J1G_F, 2J2P_A, 2J2P_B, 2J2P_C, 2J2P_D, 2J2P_E, 2J2P_F).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


FCN2 has been screened with compounds ( bioactivities). (see details)